Residual naming after damage to the left temporal pole: a PET activation study.
Residual naming after damage to the left temporal pole: a PET activation study.
复制标题
左颞极损伤后的剩余命名：PET 激活研究。
DOI：
10.1016/s1053-8119(03)00109-5
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发表时间：
2003
期刊：
影响因子：
5.7
通讯作者：
Hichwa,RichardD
中科院分区：
文献类型：
--
作者：
Grabowski,ThomasJ;Damasio,Hanna;Tranel,Daniel;Cooper,GregoryE;Ponto,LauraLBoles;Watkins,GLeonard;Hichwa,RichardD
正常受试者在命名人名时激活左颞极皮层，而左颞极因左前颞叶切除术而受损的受试者在检索人名时受损。八个这样的主题进行了研究，在PET激活实验，以解决支持他们的残留命名的神经系统。我们假设，相对于正常对照组，受损区域周围、同源右颞极或两者都有活动增加。无论是团体还是个体目标受试者都没有表现出病变周围或右颞极的活动显著增加。正常人在检索人名时激活的其他几个区域，这些区域在目标受试者中未受损（左前上级颞沟、内侧额叶皮质和前扣带回）被目标受试者激活的程度显著降低，这一发现表明，左颞极的损伤改变了提取专有名词所需的大规模系统的功能。早期视觉皮层的活动增加，这表明视觉处理的强化，以弥补有缺陷的首选名称检索处理。
Normal subjects activate the left temporal polar cortex when they name persons, and subjects with damage to the left temporal pole due to left anterior temporal lobectomy are impaired in the retrieval of the proper names of persons. Eight such subjects were studied in a PET activation experiment to address the neural systems supporting their residual naming. We hypothesized that there would be increased activity, relative to normal controls, in the surround of the damaged region, the homologous right temporal pole, or both. Neither the group nor individual target subjects showed significantly increased activity in the lesion surround or in the right temporal pole. Several other regions that are activated by normals during the retrieval of the proper names of persons and which were undamaged in the target subjects (left anterior superior temporal sulcus, mesial frontal cortex, and anterior cingulate) were nevertheless significantly less activated by the target subjects, a finding that suggests that damage to the left temporal pole alters the function of a large-scale system needed for the retrieval of proper nouns. There was increased activity in early visual cortices, suggesting intensification of visual processing to compensate for the defective preferred name retrieval processing.