AROUSAL FROM HIBERNATION BY INTRAHYPOTHALAMIC INJECTIONS OF BIOGENIC-AMINES IN GROUND SQUIRRELS
AROUSAL FROM HIBERNATION BY INTRAHYPOTHALAMIC INJECTIONS OF BIOGENIC-AMINES IN GROUND SQUIRRELS
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DOI：
10.1152/ajplegacy.1972.222.4.875
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发表时间：
1972-01-01
影响因子：
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通讯作者：
SATINOFF, E
中科院分区：
文献类型：
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作者：
BECKMAN, AL;SATINOFF, E
本文用PO/AH插管观察了NE和5-HT对6只动物冬眠觉醒过程的影响。在每种情况下，NE和5-HT启动完全唤醒从冬眠。在8个NE实验中，反应的平均潜伏期（Z~ SEM）为19 rt 3 min，达到稳定活动状态温度所需的平均时间为130 rt 13 min。平均潜伏期为40 ± 20分钟，完成唤醒所需的平均时间为150 ± 20分钟。图1显示了0.4I.cg NE和0.8pug 5-HT后从冬眠中唤醒。反应潜伏期NE为15 min，5-HT为20 min。唤醒时间过程为NE后105 min和5-HT后120 min。图1的下图显示对照注射0.2 μ g酒石酸氢钠（对照注射0.4 μ g NE）对温度和冬眠没有任何影响。为了在冬眠动物中完成实验，通常需要改变地松鼠在其巢中的姿势，以便将
RESULTSThe effects of NE and 5-HT on the process of arousal from hibernation were tested in 11 experiments on 6 animals with PO/AH cannulas. In every case, NE and 5-HT initiated complete arousal from hibernation. The average latency of response (Z~ SEM) in eight NE experiments was 19 rt 3 min, and the average time taken to reach stable active-state temperatures was 130= t 13 min. In three experiments testing 5-HT, the average latency was 40= t 20 min and the average time taken to complete arousal was 150 & 30 min. Figure 1 illustrates the arousal from hibernation after 0.4 I, cg of NE and 0.8 pug of 5-HT. The latency of response was 15 min following NE and 20 min following 5-HT. The time course of arousal was 105 min following NE and 120 min following 5-HT. The lower panel of Fig. 1 shows the absence of any effect of a control injection of 0.2 pug of sodium bitartrate(control for 0.4 pug of NE) on temperature and hibernation. In order to accomplish the experiments in hibernating animals, it was usually necessary to alter the ground squirrel’s postural position within its nest so as to insert the