Effect of age on cytokine production in humans
Effect of age on cytokine production in humans
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DOI：
10.1007/s11357-998-0024-6
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发表时间：
1998-10-01
期刊：
影响因子：
--
通讯作者：
Murasko, DM
中科院分区：
文献类型：
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作者：
Bernstein, ED;Murasko, DM
衰老伴随着免疫反应的许多变化，其中最一致和最显著的变化发生在T细胞区室中。由于细胞因子是免疫细胞通讯的核心，因此细胞因子产生的年龄相关变化可能有助于这些变化。虽然来自鼠研究的数据表明从Th 1（IL-2、IFN γ）到Th 2（IL-4、IL-6、IL-10）细胞因子应答的转换，但该模型尚未在人类中明确建立。此外，目前对50多项人类研究的回顾表明，细胞因子产生的年龄相关变化并不一致。
Aging is accompanied by many changes in immune response, with the most consistent and dramatic alterations occurring within the T cell compartment. Since cytokines are central to immune cell communications, age-associated changes in cytokine production may contribute to these alterations. While data from murine studies suggest a switch from a Th1 (IL-2, IFN gamma) to a Th2 (IL-4, IL-6, IL-10) cytokine response, this model has not been as clearly established in humans. In addition, this current review of over 50 stud ies in humans suggests that age-associated changes in cytokine production are not consistent.