Case of subepidermal autoimmune bullous disease with psoriasis vulgaris reacting to both BP180 C-terminal domain and laminin gamma-1.
Case of subepidermal autoimmune bullous disease with psoriasis vulgaris reacting to both BP180 C-terminal domain and laminin gamma-1.
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表皮下自身免疫性大疱性疾病伴有寻常型银屑病，对 BP180 C 末端结构域和层粘连蛋白 gamma-1 均有反应。
DOI：
10.1111/1346-8138.12801
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Aihara M.
中科院分区：
文献类型：
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作者：
Ishida S;Takahashi K;Kanaoka M;Okawa T;Tateishi C;Yasukochi A;Ishii N;Li X;Hashimoto T;Aihara M.
许多寻常型银屑病患者出现大疱性皮肤病变，被诊断为大疱性类天疱疮伴180 kDa大疱性类天疱疮抗原（BP 180）非胶原16 a（NC 16 a）结构域抗体或抗层粘连蛋白-γ1（p200）类天疱疮。我们报告一例表皮下大疱性疾病伴寻常型银屑病，显示BP 180 C末端结构域和层粘连蛋白γ1抗体。一名患有寻常型银屑病的64岁日本男性全身出现渗出性水疱和紧张性大疱，但未累及粘膜。组织病理学上，水疱性病变表现为表皮下水疱。在1 mol/L NaCl-分裂皮肤的间接免疫荧光中，免疫球蛋白（IG）G抗体与表皮和真皮侧均发生反应。免疫印迹显示正常人皮肤提取物中含有BP 180 C末端结构域和200-kDa层粘连蛋白-γ1的重组蛋白的IgG阳性。
A number of cases of psoriasis vulgaris developing bullous skin lesions have been diagnosed as either bullous pemphigoid with antibodies to the 180‐kDa bullous pemphigoid antigen (BP180) non‐collagenous 16a (NC16a) domain or anti‐laminin‐γ1 (p200) pemphigoid. We report a case of subepidermal bullous disease with psoriasis vulgaris, showing antibodies to both BP180 C‐terminal domain and laminin‐γ1. A 64‐year‐old Japanese man with psoriasis vulgaris developed exudative erythemas and tense bullae on the whole body but he did not have mucosal involvement. The blistering lesion showed subepidermal blisters histopathologically. In indirect immunofluorescence of 1 mol/L NaCl‐split skin, immunoglobulin (Ig)G antibodies reacted with both the epidermal and dermal side. Immunoblotting showed positive IgG with recombinant protein of BP180 C‐terminal domain and 200‐kDa laminin‐γ1 in normal human dermal extract.