Circulating micrornas associated with glycemic impairment and progression in Asian Indians.
Circulating micrornas associated with glycemic impairment and progression in Asian Indians.
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DOI：
10.1186/s40364-015-0047-y
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发表时间：
2015
影响因子：
11.1
通讯作者：
Kanaya AM
中科院分区：
文献类型：
--
作者：
Flowers E;Gadgil M;Aouizerat BE;Kanaya AM
亚裔印度人2型糖尿病发病率高，但与该人群血糖进展相关的因素尚不清楚。microRNA正在成为葡萄糖稳态的重要介质，以前没有在亚洲印度人中进行过研究。我们检测了来自旧金山弗朗西斯科湾区的亚裔印度人中与血糖受损和进展相关的microRNA（miR）表达。我们研究了128名45-84岁的亚洲印度人，他们没有已知的心血管疾病，也没有服用糖尿病药物。在基线和2.5年后进行口服葡萄糖耐量试验。我们使用基于流式细胞术的测定对来自在招募访视期间收集的血浆的循环miR进行定量。基线时，57%（n = 73）的患者存在糖化血红蛋白受损。miR-191与血糖损害正相关（比值比（OR）1.7（95%CI 1.2，2.4），p < 0.01）。2.5年后血糖进展的患病率为24%（n = 23）。6种miR与血糖进展呈负相关：miR-122（OR 0.5（0.2，0.8），p < 0.01），miR-15a（OR 0.6（0.4，0.9），p < 0.01），miR-197（OR 0.6（0.4，0.9），p < 0.01）、miR-320 a（OR 0.6（0.4，0.9），p < 0.01）、miR-423（OR 0.6（0.4，0.9），p < 0.01）和miR-486（OR 0.5（0.3，0.8），p < 0.01）。进一步的多变量调整并没有减弱这些结果。这是第一项研究与血糖状态相关的循环miR在这个高风险的种族群体。单个miR与血糖损害和血糖进展显著相关。需要进一步研究以确定miR是否可能是亚洲印度人群中T2 D事件的有用临床生物标志物。本文的在线版本（doi：10.1186/s40364-015-0047-y）包含补充材料，可供授权用户使用。
Asian Indians have a high incidence of type 2 diabetes, but factors associated with glycemic progression in this population are not understood. MicroRNAs are emerging as important mediators of glucose homeostasis and have not been previously studied in Asian Indians. We examined microRNA (miR) expression associated with glycemic impairment and progression in Asian Indians from the San Francisco Bay Area. We studied 128 Asian Indians age 45–84 years without known cardiovascular disease and not taking diabetes medications. Oral glucose tolerance tests were performed at baseline and after 2.5 years. We quantified circulating miRs from plasma collected during the enrollment visit using a flow cytometry-based assay. Glycemic impairment was present in 57 % (n = 73) at baseline. MiR-191 was positively associated with glycemic impairment (odds ratio (OR) 1.7 (95 % CI 1.2, 2.4), p < 0.01). The prevalence of glycemic progression after 2.5 years was 24 % (n = 23). Six miRs were negatively associated with glycemic progression: miR-122 (OR 0.5 (0.2, 0.8), p < 0.01), miR-15a (OR 0.6 (0.4, 0.9), p < 0.01), miR-197 (OR 0.6 (0.4, 0.9), p < 0.01), miR-320a (OR 0.6 (0.4, 0.9), p < 0.01), miR-423 (OR 0.6 (0.4, 0.9), p < 0.01), and miR-486 (OR 0.5 (0.3, 0.8), p < 0.01). Further multivariate adjustment did not attenuate these results. This is the first study to investigate circulating miRs associated with glycemic status among this high-risk ethnic group. Individual miRs were significantly associated with both glycemic impairment and glycemic progression. Further studies are needed to determine whether miR (s) might be useful clinical biomarkers for incident T2D in the Asian Indian population. The online version of this article (doi:10.1186/s40364-015-0047-y) contains supplementary material, which is available to authorized users.