Dynamics of Cell Generation and Turnover in the Human Heart
Dynamics of Cell Generation and Turnover in the Human Heart
复制标题
DOI：
10.1016/j.cell.2015.05.026
复制
发表时间：
2015-06-18
期刊：
影响因子：
64.5
通讯作者：
Frisen, Jonas
中科院分区：
文献类型：
--
作者：
Bergmann, Olaf;Zdunek, Sofia;Frisen, Jonas
细胞生成对人类心脏生理生长和维持的贡献一直难以确定，并且仍然存在争议。我们报告说，完整的心肌细胞是围产期建立，并保持稳定的人的一生，而内皮细胞和间充质细胞的数量从出生到成年早期大幅增加。对原子弹试验衍生的C-14整合的分析显示，在整个生命过程中，内皮细胞的更新率很高（每年>15%），而间充质细胞的更新更有限（
The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived C-14 revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (