The CHEK2 I157T Variant and Breast Cancer Susceptibility: A Systematic Review and Meta-analysis
The CHEK2 I157T Variant and Breast Cancer Susceptibility: A Systematic Review and Meta-analysis
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CHEK2 I157T 变异和乳腺癌易感性：系统评价和荟萃分析
DOI：
10.7314/apjcp.2012.13.4.1355
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Wang, Ya-Jie
中科院分区：
文献类型：
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作者：
Liu, Chuan;Wang, Ying;Wang, Ya-Jie
背景资料：细胞周期检查点激酶2（CHEK 2）基因I157 T变异可能与乳腺癌风险增加有关，但目前尚不清楚是否有足够的证据建议在临床实践中进行突变检测。材料与方法：系统检索PubMed、Embase、Elsevier和Springer 2011年11月之前发表的相关文献。使用随机效应模型和STATA（版本10.0）软件计算总比值比（OR）和95%置信区间（95% CI）发生率。结果：共纳入15个病例对照研究，包括19，621例病例和27，001例对照。CHEK 2 I157 T变异与乳腺癌的发生有显著相关性（OR = 1.48，95%CI = 1.31-1.66，P
Background: The cell cycle checkpoint kinase 2 (CHEK2) gene I157T variant may be associated with an increased risk of breast cancer, but it is unclear whether the evidence is sufficient to recommend testing for the mutation in clinical practice. Materials and Methods: We systematically searched PubMed, Embase, Elsevier and Springer for relevant articles published before Nov 2011. Summary odds ratio (OR) and 95% confidence interval (95% CI) incidence rates were calculated using a random-effects model with STATA (version 10.0) software. Results: A total of fifteen case-control studies, including 19,621 cases and 27,001 controls based on the search criteria, were included for analysis. A significant association was found between carrying the CHEK2 I157T variant and increased risk of unselected breast cancer (OR = 1.48, 95% CI = 1.31-1.66, P