Effects of dexamethasone in hypoxic-ischemic brain injury in the neonatal rat.
Effects of dexamethasone in hypoxic-ischemic brain injury in the neonatal rat.
复制标题
地塞米松对新生大鼠缺氧缺血性脑损伤的影响。
DOI：
10.1159/000242058
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
S. Yagel
中科院分区：
文献类型：
--
作者：
Denis I. Altman;Richard S. K. Young;S. Yagel
为探讨糖皮质激素在新生大鼠缺氧缺血性脑损伤中的作用，将7日龄大鼠单侧颈总动脉结扎，皮下注射生理盐水、低剂量地塞米松（4 mg/kg）或高剂量地塞米松（40 mg/kg）后进行缺氧（Levine程序）。无论是低剂量还是高剂量地塞米松都不能改善与缺氧缺血相关的脑水肿、乳酸血症或低血糖。此外，地塞米松没有改变神经病理损伤的模式或减少脑高能磷酸盐的下降。最后，高剂量地塞米松治疗的动物经历了显着更多的死亡率比盐水或低剂量地塞米松治疗的动物。在这个新生儿缺氧缺血模型中，地塞米松没有提供任何显着的脑保护。
To clarify the effects of corticosteroids in neonatal hypoxic-ischemic brain injury, 7-day-old rats were subjected to unilateral common carotid artery ligation and hypoxia (Levine procedure) after being injected subcutaneously with saline, low-dose dexamethasone (4 mg/kg) or high-dose dexamethasone (40 mg/kg). Neither low-dose nor high-dose dexamethasone ameliorated the brain edema, lactacidemia, or hypoglycemia associated with hypoxia-ischemia. In addition, dexamethasone did not alter the pattern of neuropathologic damage or reduce the fall in brain high-energy phosphates. Finally, high-dose dexamethasone-treated animals experienced significantly more mortality than did either saline- or low-dose dexamethasone-treated animals. In this model of neonatal hypoxia-ischemia, dexamethasone did not confer any significant cerebral protection.