Cardiovascular Risk Assessment with Vascular Function, Carotid Atherosclerosis and the UKPDS Risk Engine in Korean Patients with Newly Diagnosed Type 2 Diabetes.
Cardiovascular Risk Assessment with Vascular Function, Carotid Atherosclerosis and the UKPDS Risk Engine in Korean Patients with Newly Diagnosed Type 2 Diabetes.
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DOI：
10.4093/dmj.2011.35.6.619
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发表时间：
2011-12
影响因子：
5.9
通讯作者：
Han KA
中科院分区：
文献类型：
--
作者：
Seon CS;Min KW;Lee SY;Nho KW;Park SH;Koo BK;Han KA
2型糖尿病患者患心血管疾病的风险增加。很少有研究同时使用英国前瞻性糖尿病研究（UKPDS）风险引擎和新诊断的2型糖尿病患者的非侵入性血管检查来评估心血管疾病（CVD）风险。参与者（n=380;年龄20至81岁）与新诊断的2型糖尿病是免费的心血管疾病的临床证据。使用UKPDS风险引擎计算每位患者的10年冠心病（CHD）和中风风险。测量颈动脉内膜中层厚度（CIMT）、血流介导的血管扩张（FMD）、脉搏波传导速度（PWV）和血管扩张指数（AI）。UKPDS风险引擎和非侵入性血管测试之间的相关性进行了评估，使用偏相关分析，调整年龄后，和多元回归分析。平均10年冠心病和10年脑卒中风险分别为14.92±11.53%和4.03± 3.95%。校正年龄后，10年CHD风险与CIMT（P<0.001）、FMD（P=0.017）和PWV（P=0.35）相关。校正年龄后，10年卒中风险仅与平均CIMT相关（P<0.001）。FMD与年龄（P<0.01）和收缩压（P=0.09）相关。CIMT与年龄（P<0.01）、HbA 1c（P=0.05）和性别（P<0.01）相关。2型糖尿病患者的心血管疾病风险增加。CIMT、FMD和PWV沿着UKPDS风险引擎应被考虑用于评估新诊断的2型糖尿病患者的心血管疾病风险。
Patients with type 2 diabetes have an increased risk of cardiovascular disease. Few studies have evaluated the cardiovascular disease (CVD) risk simultaneously using the United Kingdom Prospective Diabetes Study (UKPDS) risk engine and non-invasive vascular tests in patients with newly diagnosed type 2 diabetes. Participants (n=380; aged 20 to 81 years) with newly diagnosed type 2 diabetes were free of clinical evidence of CVD. The 10-year coronary heart disease (CHD) and stroke risks were calculated for each patient using the UKPDS risk engine. Carotid intima media thickness (CIMT), flow mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AI) were measured. The correlations between the UKPDS risk engine and the non-invasive vascular tests were assessed using partial correlation analysis, after adjusting for age, and multiple regression analysis. The mean 10-year CHD and 10-year stroke risks were 14.92±11.53% and 4.03±3.95%, respectively. The 10-year CHD risk correlated with CIMT (P<0.001), FMD (P=0.017), and PWV (P=0.35) after adjusting for age. The 10-year stroke risk correlated only with the mean CIMT (P<0.001) after adjusting for age. FMD correlated with age (P<0.01) and systolic blood pressure (P=0.09). CIMT correlated with age (P<0.01), HbA1c (P=0.05), and gender (P<0.01). The CVD risk is increased at the onset of type 2 diabetes. CIMT, FMD, and PWV along with the UKPDS risk engine should be considered to evaluate cardiovascular disease risk in patients with newly diagnosed type 2 diabetes.