Impact of p53 aberration on the progression of Adult T-cell Leukemia/Lymphoma
Impact of p53 aberration on the progression of Adult T-cell Leukemia/Lymphoma
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DOI：
10.1016/j.canlet.2005.03.039
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发表时间：
2006-03-28
期刊：
影响因子：
9.7
通讯作者：
Kamihira, S
中科院分区：
文献类型：
--
作者：
Tawara, M;Hogerzeil, SJ;Kamihira, S
基于其年龄依赖性发生的统计分析，提出了成人T细胞白血病/淋巴瘤（ATLL）的多步致癌模型。我们以前曾报道过p16基因的缺失是ATLL进展的关键事件。在本研究中，我们首次报道了p16和p53的畸变在ATLL中是相互排斥的，并且这两种事件中的任何一种都足以导致ATLL的进展。超过一半的患者有两种畸变之一，这两种畸变都是预后不良的重要标志。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Based on statistical analysis of its age-dependent occurrence, a multi-step carcinogenesis model has been proposed for Adult T-cell Leukemia/Lymphoma (ATLL). We have previously reported that the deletion of the p16 gene is a key event in ATLL progression. In the current study, we report for the first time that the aberrations of p16 and p53 are mutually exclusive in ATLL and either of the two events is sufficient for the ATLL progression. More than half of the patients had one of the two aberrations, and both aberrations emerged as significant markers for a poor prognosis. (c) 2005 Elsevier Ireland Ltd. All rights reserved.