Salivary biomarkers for periodontal disease diagnostics.
Salivary biomarkers for periodontal disease diagnostics.
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DOI：
10.1517/17530059.2011.542144
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Wong, David T
中科院分区：
文献类型：
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作者：
Brinkmann, Ole;Zhang, Lei;Wong, David T
该领域的重要性：牙周病是所有疾病中最流行的疾病之一。慢性炎症过程导致牙齿脱落，并与负面的全身效应有关。在精确诊断、预后和适当的疾病治疗方面仍然存在重大挑战。快速崛起的唾液诊断领域可能有助于克服这些问题。本综述涵盖的领域：本文涵盖了过去20年的牙周病生物标志物研究，并概述了唾液诊断技术的现状。读者将深入了解牙周病的过程，唾液分子诊断领域的相关生物标志物和生物标志物检测技术。牙周病的诊断、治疗和预后将受益于这一新兴的诊断领域。
IMPORTANCE OF THE FIELD: Periodontal disease is one of the most prevalent of all diseases. The chronic inflammatory process causes tooth loss and is associated with negative systemic effects. There are still major challenges when it comes to precise diagnosis, prognosis and appropriate disease therapy. The rapidly emerging field of salivary diagnostics could help to overcome these problems.AREAS COVERED IN THIS REVIEW: The article covers the last 20 years of periodontal disease biomarker research and gives an overview of the current status of salivary diagnostic techniques.WHAT THE READER WILL GAIN: The reader will gain insight into the periodontopathic process, associated biomarkers and biomarker detection techniques in the field of saliva-based molecular diagnostics.TAKE HOME MESSAGE: Salivary diagnostics has great potential for the detection of oral and systemic diseases. Periodontal disease diagnostics, therapy and prognosis could benefit from this emerging diagnostic field.