Deep Venous Thrombosis and Lupus Anticoagulant
Deep Venous Thrombosis and Lupus Anticoagulant
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深静脉血栓形成和狼疮抗凝剂
DOI：
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发表时间：
1996
影响因子：
6.7
通讯作者：
A. Girolami
中科院分区：
文献类型：
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作者：
P. Simioni;P. Prandoni;E. Zanon;M. Saracino;A. Scudeller;S. Villalta;L. Scarano;B. Girolami;L. Benedetti;A. Girolami
摘要背景。在没有系统性红斑狼疮的患者中，支持深静脉血栓形成（DVT）与狼疮抗凝物（LA）相关的确切证据仍然缺乏。方法.在一项病例对照研究中，确定了176例连续门诊患者的LA，这些患者因临床怀疑下肢DVT首次发作而接受静脉造影。DVT和LA之间的关联使用比值比（OR）进行描述。结果静脉造影证实59例（33.5%）。在59例DVT患者中有5例（8.5%）检测到LA，而在117例静脉造影正常的受试者中没有检测到LA（P = 0.007）。LA患者发生急性DVT的OR为10.7（95% CI：1.2-94.2）。结论.在有症状的患者中，LA与DVT显著相关。需要进一步的研究来确定这种关联的临床意义。
Summary Background. A definite evidence in favour of an association of deep-vein thrombosis (DVT) with lupus anticoagulant (LA) in patients free from systemic lupus erythematosus is still lacking. Methods. In a case-control study, LA was determined in 176 consecutive outpatients who underwent phlebography because of the first episode of clinically suspected DVT of lower limbs. The association between DVT and LA was described using odds ratios (OR). Results. Contrast venography confirmed the clinical suspicion in 59 patients (33.5%). LA was detected in 5 of the 59 patients with DVT (8.5%), and in none of the 117 subjects with normal venogram (P = 0.007). The OR for having an acute DVT in patients with LA was 10.7 (95% CI: 1.2-94.2). Conclusions. LA is significantly associated with DVT in symptomatic patients. Further studies are needed to establish the clinical implications of this association.