Eosinophils and other peripheral blood biomarkers in glioma grading: a preliminary study
Eosinophils and other peripheral blood biomarkers in glioma grading: a preliminary study
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嗜酸性粒细胞和其他外周血生物标志物在神经胶质瘤分级中的作用：初步研究
DOI：
10.1186/s12883-019-1549-2
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发表时间：
2019-12-05
期刊：
影响因子：
2.6
通讯作者：
Xie, Jian
中科院分区：
文献类型：
--
作者：
Huang, Zhenxing;Wu, Liang;Xie, Jian
背景：许多外周血生物标志物与胶质瘤分级相关，但嗜酸性粒细胞（Eo）的研究报道较少。本研究评估了术前外周血嗜酸性粒细胞水平和其他外周血生物标志物在以往文献中提出的，探讨其关联和诊断价值的胶质瘤，包括其最具侵袭性的类型，胶质母细胞瘤（GBM）。方法：纳入新诊断的神经上皮肿瘤患者，并分为低级别胶质瘤（LGG）/高级别胶质瘤（HGG）和非GBM/GBM组分别。收集术前外周血生物标志物，如Eo、中性粒细胞（Neu）和淋巴细胞（Ly）计数，并计算嗜酸性粒细胞与淋巴细胞比率（ELR）和中性粒细胞与淋巴细胞比率（NLR）等数值。还在这些生物标志物和组之间进行相关性分析。结果：HGG患者的Eo和ELR值较低，与胶质瘤分级呈负相关。Eo和ELR联合其他生物标志物可提高诊断效率。在non-GBM vs GBM分析中，GBM患者显示Eo降低，Eo与GBM诊断呈负相关，Eo与其他生物标志物的组合增强了诊断效率。结论：在我们的研究中发现外周血嗜酸性粒细胞与胶质瘤分级呈负相关。嗜酸性粒细胞来源的多种细胞因子可以调节免疫反应，影响肿瘤微环境，并可能抑制胶质瘤的发生，这一点值得进一步研究，为胶质瘤的治疗开辟新的途径。
Background: Many peripheral blood biomarkers are associated with glioma grade, but eosinophils (Eo) are scarcely reported. This study assessed preoperative peripheral eosinophil levels and other peripheral biomarkers presented in prior literature, probing their associations and diagnostic value in the grading of glioma, including its most aggressive type, glioblastoma (GBM).Methods: Patients newly diagnosed with neuroepithelial tumors were included and divided into low-grade glioma (LGG)/high-grade glioma (HGG) groups and non-GBM/GBM groups separately. Preoperative peripheral biomarkers were collected, such as the counts of Eo, neutrophils (Neu), and lymphocytes (Ly), and values such as the eosinophil to lymphocyte ratio (ELR) and neutrophil to lymphocyte ratio (NLR) were calculated. Correlation analyses were also performed between these biomarkers and the groups. Receiver operating characteristic curves were utilized to assess the individual and joint diagnostic values of the biomarkers.Results: The HGG patients presented lower Eo and ELR values, which had negative correlations with glioma grade. The diagnostic efficiency of Eo and ELR could be enhanced when combined other biomarkers. In the non-GBM vs GBM analysis, GBM patients displayed reduced Eo and a negative correlation between Eo and a GBM diagnosis The combination of Eo and other biomarkers enhanced the diagnostic efficiency.Conclusions: A negative correlation between peripheral eosinophils and glioma grade was found in our study. Numerous cytokines derived from eosinophils could regulate the immune response and affect the tumor microenvironment; moreover, eosinophils may inhibit the tumorigenesis of glioma, which should be explored in the future and may enlighten some new paths for glioma therapy.