Measurement of offline exhaled nitric oxide in a study of community exposure to air pollution.
Measurement of offline exhaled nitric oxide in a study of community exposure to air pollution.
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DOI：
10.1289/ehp.6160
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发表时间：
2003-10
影响因子：
10.4
通讯作者：
Larson, T V
中科院分区：
文献类型：
--
作者：
Koenig, J Q;Jansen, K;Mar, T F;Lumley, T;Kaufman, J;Trenga, C A;Sullivan, J;Liu, L-J S;Shapiro, G G;Larson, T V
作为在西雅图，华盛顿的一个大型小组研究的一部分，我们测量了呼出的一氧化氮（eNO）在儿童的家庭和固定位置的空气动力学直径为2.5微米或更小的颗粒物（PM（2.5））在2000-2001年的冬季和春季会议的家庭内外，以及个人PM（2.5）的水平。19例6-13岁的受试者参与研究; 19例受试者中有9例接受吸入性皮质类固醇（ICS）治疗。连续10天将呼气测量值离线收集到Mylar球囊中。冬季会议的平均eNO值为19.1（SD +/- 11.4）ppb，春季会议为12.5 +/- 6.6 ppb。固定地点的PM（2.5）平均浓度为10.1 +/- 5.7微克/立方米（3）的家庭和13.3 +/- 1.4的家庭内;个人PM（2.5）平均值为13.4 +/- 3.2微克/立方米（3）。我们使用了一个线性混合效应模型，随机截距和药物的相互作用项，以测试eNO和各种PM（2.5）值之间的受试者内-会话内关联。我们发现，从室外、室内、个人和中心站点测量的PM（2.5）增加10微克/立方米，这与所有受试者在滞后第0天的eNO增加有关。室外监护仪的影响为4.3 ppb [95%置信区间（CI），1.4-7.29]，室内监护仪为4.2 ppb（95% CI，1.02-7.4），个人监护仪为4.5 ppb（95% CI，1.02-7.9），中央监护仪为3.8 ppb（95% CI，1.2-6.4）。药物类别的相互作用项（ICS使用者vs.非使用者）在所有分析中均具有显著性。这些结果表明，eNO可以作为一种评估工具，在流行病学研究的空气污染对健康的影响。
As part of a large panel study in Seattle, Washington, we measured levels of exhaled nitric oxide (eNO) in children's homes and fixed-site particulate matter with aerodynamic diameters of 2.5 micro m or less (PM(2.5)) outside and inside the homes as well as personal PM(2.5) during winter and spring sessions of 2000-2001. Nineteen subjects 6-13 years of age participated; 9 of the 19 were on inhaled corticosteroid (ICS) therapy. Exhaled breath measurements were collected offline into a Mylar balloon for up to 10 consecutive days. Mean eNO values were 19.1 (SD +/- 11.4) ppb in winter sessions and 12.5 +/- 6.6 ppb in spring sessions. Fixed-site PM(2.5) mean concentrations were 10.1 +/- 5.7 microg/m(3) outside homes and 13.3 +/- 1.4 inside homes; the personal PM(2.5) mean was 13.4 +/- 3.2 microg/m(3). We used a linear mixed-effects model with random intercept and an interaction term for medications to test for within-subject-within-session associations between eNO and various PM(2.5) values. We found a 10 microg/m(3) increase in PM(2.5) from the outdoor, indoor, personal, and central-site measurements that was associated with increases in eNO in all subjects at lag day zero. The effect was 4.3 ppb [95% confidence interval (CI), 1.4-7.29] with the outdoor monitor, 4.2 ppb (95% CI, 1.02-7.4) for the indoor monitor, 4.5 ppb (95% CI, 1.02-7.9) with the personal monitor, and 3.8 ppb (95% CI, 1.2-6.4) for the central monitors. The interaction term for medication category (ICS users vs. nonusers) was significant in all analyses. These findings suggest that eNO can be used as an assessment tool in epidemiologic studies of health effects of air pollution.