Hospitalizations Related To Opioid Abuse/Dependence And Associated Serious Infections Increased Sharply, 2002-12.
Hospitalizations Related To Opioid Abuse/Dependence And Associated Serious Infections Increased Sharply, 2002-12.
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DOI：
10.1377/hlthaff.2015.1424
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发表时间：
2016-05-01
期刊：
影响因子：
--
通讯作者：
Herzig SJ
中科院分区：
文献类型：
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作者：
Ronan MV;Herzig SJ
严重感染是公认的静脉药物滥用并发症，也是该患者群体发病和死亡的主要原因。此前尚未在美国阿片类药物使用流行的背景下调查与阿片类药物滥用/依赖相关的严重感染的发生率和相关成本的趋势。我们的研究使用了美国住院患者的全国代表性样本，结果表明，从 2002 年到 2012 年，与阿片类药物滥用/依赖相关的住院治疗和与阿片类药物滥用/依赖相关严重感染相关的住院治疗均显着增加，分别从 301,707 例增加到 520,275 例，从 3,421 例增加到 6,535 例。此外，两种类型住院的住院费用在同一时期几乎翻了两番，2012 年与阿片类药物滥用/依赖相关的住院费用总额达到近 150 亿美元，与相关感染相关的住院费用总额超过 7 亿美元。医疗补助是这两种类型住院费用最常见的主要支付方。我们的结果描述了与阿片类药物滥用/依赖相关的医疗保健系统的经济负担以及这种流行病更严重的下游并发症之一。这些发现对于不成比例地承担这些费用的医院和政府机构，以及对估计有针对性的公共卫生干预措施在国家层面的潜在影响感兴趣的临床医生、研究人员和政策制定者具有重要意义。
Serious infection is a recognized complication of intravenous drug abuse, and a major cause of morbidity and mortality in this patient population. Trends in rates and the associated cost of serious infections related to opioid abuse/dependence have not been previously investigated in the context of the US opioid use epidemic. Our study, using a nationally representative sample of U.S. inpatient hospitalizations, showed that hospitalizations related to opioid abuse/dependence and hospitalizations related to opioid abuse/dependence with associated serious infection both significantly increased from 2002 to 2012, respectively, from 301,707 to 520,275 and 3,421 to 6,535. Additionally, inpatient charges for both types of hospitalizations have almost quadrupled over the same time period, reaching totals of almost 15 billion for hospitalizations related to opioid abuse/dependence and more than 700 million for those related to associated infection in 2012. Medicaid was the most common primary payer for both types of hospitalizations. Our results characterize the financial burden on the healthcare system related to opioid abuse/dependence and one of the more serious downstream complications of this epidemic. These findings have important implications for the hospitals and government agencies that disproportionately shoulder these costs, and for clinicians, researchers, and policy makers interested in estimating the potential impact of targeted public health interventions on a national level.