EFFECT OF ADENOSINE ON CAROTID CHEMORECEPTOR ACTIVITY IN THE CAT
EFFECT OF ADENOSINE ON CAROTID CHEMORECEPTOR ACTIVITY IN THE CAT
复制标题
腺苷对猫颈动脉化学感受器活性的影响
DOI：
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发表时间：
1981
影响因子：
7.3
通讯作者：
J. Ribeiro
中科院分区：
文献类型：
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作者：
D. McQueen;J. Ribeiro
在戊巴比酮麻醉的猫的颈动脉内（即）注射或输注腺苷对化学感受器活性的影响已被研究。2腺苷注射（0.1-100 μg）引起自发化学感受器放电的迅速和显著增加，其强度、持续时间和发作是剂量依赖性的。腺苷（50 μg/min）的输注也引起放电的增加，这种增加持续输注的时间。茶碱（1 mg）和氨茶碱（1 mg）均引起短时的自发放电减少，但没有阻止腺苷的兴奋作用。纳洛酮（400 μg）可拮抗吗啡对化学感受器放电的抑制作用，但不能拮抗腺苷5的兴奋作用。由此可见，外源性腺苷可使猫颈动脉化学感受器兴奋，且在所研究的剂量范围内，茶碱不能阻止这一作用。讨论了研究结果的生理意义。
1 The effects of intracarotid (i.e.) injections or infusions of adenosine on chemoreceptor activity recorded from the peripheral end of a sectioned carotid sinus nerve have been studied in cats anaesthetized with pentobarbitone 2 Adenosine injections (0.1–100 μg) caused a rapid and marked increase of spontaneous chemoreceptor discharge, the intensity, duration and onset of which was dose‐dependent. Infusion of adenosine, 50 μg/min, also evoked an increase in discharge which persisted for the duration of the infusion 3 Both theophylline (1 mg i.e.) and aminophylline (1 mg i.e.) caused short‐lasting decreases in spontaneous discharge but did not prevent the excitatory effect of adenosine. Theophylline increased the excitatory action of adenosine 4 Naloxone (400 μg i.e.) antagonized the depressant effect of morphine on chemoreceptor discharge but not the excitatory action of adenosine 5 It is concluded that exogenous adenosine can excite the cat carotid chemoreceptors, an effect which is not prevented by theophylline in the doses studied. The physiological significance of the findings is discussed.