Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms
Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms
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DOI：
10.1016/s0046-8177(96)90364-0
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发表时间：
1996-02-01
期刊：
影响因子：
3.3
通讯作者：
Hruban, RH
中科院分区：
文献类型：
--
作者：
Day, JD;Digiuseppe, JA;Hruban, RH
虽然一些形态学和分子遗传学研究表明，不同程度的胰管增生是浸润性胰腺癌的前病变，但浸润前胰腺肿瘤的身份仍存在争议。在本研究中，作者检测了表皮生长因子受体同源物HER-2/neu（c-erbB-2）在一系列19例胰腺导管腺癌中浸润性胰腺癌旁胰腺导管病变中的表达。HER-2/neu的表达进行了检查，因为它已被确定在浸润性胰腺癌的比例，因为它可能提供了一个早期肿瘤的生长优势，超过相邻的非肿瘤上皮。在正常胰腺导管和小导管中，HER-2/neu表达在所有情况下，但一个案件缺席。相比之下，HER-2/neu表达于82%（P = 0.008 vs正常）的扁平粘液性增生导管、86%（P = 0.03 vs正常）的乳头状粘液性增生导管（不伴乳头状粘液性增生）、92%（P = 0.001 vs正常）的非典型乳头状粘液性增生导管和所有原位癌标本。HER-2/neu在69%的中分化浸润癌中表达（P = 0.002 vs正常），而在低分化浸润癌中无表达。这些数据建立HER-2/neu作为一个潜在的介质的生长因子相关的信号转导在胰管病变，并提供额外的支持的假设，病变以前被认为是不同程度的增生，而不是可能代表上皮内肿瘤与潜在的后续入侵和转移。版权所有（C）1996由W.B.桑德斯公司
Although several morphological and molecular genetic studies have implicated various grades of pancreatic duct hyperplasia as precursor lesions to infiltrating pancreatic adenocarcinoma, the identity of preinvasive pancreatic neoplasms remains controversial. In the present study, the authors examined the expression of the epidermal growth factor receptor homologue, HER-2/neu (c-erbB-2), in pancreatic duct lesions adjacent to infiltrating pancreas cancers in a series of 19 cases of pancreatic duct adenocarcinoma. HER-2/neu expression was examined because it has been identified in a proportion of infiltrating pancreas cancers and because it may provide early neoplasms with a growth advantage over adjacent nonneoplastic epithelium. In normal pancreatic ducts and ductules, HER-2/neu expression was absent in all but one case. By contrast HER-2/neu was expressed in 82% (P = .008 vs normal) of ducts with flat mucinous hyperplasia, 86% (P = .03 vs normal) of ducts with papillary mucinous hyperplasia without atypia, 92% (P = .001 vs normal) of ducts with atypical papillary mucinous hyperplasia, and all specimens with carcinoma in situ. HER-2/neu expression was observed in 69% (P = .002 vs normal) of the moderately differentiated infiltrating carcinomas and none of the poorly differentiated infiltrating carcinomas. These data establish HER-2/neu as a potential mediator of growth factor-related signal transduction in pancreatic duct lesions, and provide additional support for the hypothesis that lesions formerly regarded as various grades of hyperplasia instead may represent intraepithelial neoplasms with the potential for subsequent invasion and metastasis. Copyright (C) 1996 by W.B. Saunders Company.