Impact of kidney function and urinary protein excretion on pulmonary function in Japanese patients with chronic kidney disease.
Impact of kidney function and urinary protein excretion on pulmonary function in Japanese patients with chronic kidney disease.
复制标题
日本慢性肾病患者肾功能和尿蛋白排泄对肺功能的影响。
DOI：
10.1007/s10157-013-0920-7
复制
发表时间：
2014
期刊：
影响因子：
2.3
通讯作者：
Wada T.
中科院分区：
文献类型：
--
作者：
Nakade Y;Toyama T;Furuichi K;Kitajima S;Ohkura N;Sagara A;Shinozaki Y;Hara A;Kitagawa K;Shimizu M;Iwata Y;Oe H;Nagahara M;Horita H;Sakai Y;Kaneko S;Wada T.
背景虽然慢性肾脏病的心肾关系已被研究，但有关肺肾关系的信息有限。在这里，我们调查了肾功能和尿蛋白排泄对肺功能不全的影响。MethodsThe数据从肺功能测试和肾功能（估计肾小球滤过率[eGFR]和尿蛋白）2005年4月1日至2010年6月30日期间，从我们的实验室数据库中选择。根据eGFR和蛋白尿将数据分为4类。1类：eGFR ≥60 ml/min/1.73 m2且尿蛋白<0.3 g/gCr; 2类：eGFR <60 ml/min/1.73 m2且尿蛋白<0.3 g/gCr; 3类：eGFR ≥60 ml/min/1.73 m2且尿蛋白≥0.3 g/gCr; 4类：eGFR <60 ml/min/1.73 m2且尿蛋白≥0.3 g/gCr。根据这4个category.ResultsA共133名参与者没有重大呼吸系统疾病，异常的计算机断层扫描和吸烟史进行了评估肺功能数据。血红蛋白（Hb）校正的一氧化碳弥散量百分比（%DLCO）在4类（46.2 ± 7.5）和2类（63.6 ± 17.8）中显著低于1类（75.8 ± 18.9）（P< 0.05）。此外，在尿蛋白<0.3 g/gCr的受试者中，Hb-dlco与eGFR呈弱相关（R= 0.30，P = 0.001）。在尿蛋白≥ 0.3g/gCr的受试者中，Hb-DLCO与eGFR显著相关（R= 0.81，P < 0.001）。其他肺功能检测指标（百分比（%）肺活量，%用力呼气容积在一秒（FEV 1），FEV 1/用力肺活量，%总肺容量，%残气量）是没有显着不同categoris.ConclusionThis研究表明，降低eGFR与降低%DLCO蛋白尿患者。
BackgroundAlthough the cardiorenal relationship in chronic kidney disease has been investigated, information about the lung−kidney relationship is limited. Here, we investigated the impact of kidney function and urinary protein excretion on pulmonary dysfunction.MethodsThe data from pulmonary function tests and kidney function (estimated glomerular filtration rate [eGFR] and urinary protein) between 1 April 2005 and 30 June 2010 were selected from our laboratory database. Data were classified into 4 categories according to eGFR and proteinuria. Category 1, eGFR ≥60 ml/min/1.73 m2and urinary protein <0.3 g/gCr; category 2, eGFR <60 ml/min/1.73 m2and urinary protein <0.3 g/gCr; category 3, eGFR ≥60 ml/min/1.73 m2and urinary protein ≥0.3 g/gCr; and category 4, eGFR <60 ml/min/1.73 m2and urinary protein ≥0.3 g/gCr. Pulmonary function data were evaluated according to these 4 categories.ResultsA total of 133 participants without major respiratory disease, abnormal computed tomography and smoking history were enrolled. Hemoglobin (Hb)-adjusted percentage carbon monoxide diffusing capacity (%DLCO) in category 4 (46.2 ± 7.5) and category 2 (63.6 ± 17.8) were significantly lower than in category 1 (75.8 ± 18.9) (P< 0.05). In addition, Hb-adjusted %DLCOwas weakly correlated with eGFR in participants with urinary protein <0.3 g/gCr (R= 0.30,P= 0.001). Hb-adjusted %DLCOwas strongly correlated with eGFR in participants with urinary protein ≥0.3 g/gCr (R= 0.81,P< 0.001). Other pulmonary function test markers (percentage (%) vital capacity, % forced expiratory volume in one second (FEV1), FEV1/forced vital capacity, % total lung capacity, and % residual volume) were not significantly different between categories.ConclusionThis study suggests that decreased eGFR is associated with decreased %DLCOin proteinuric patients.