Catalytic asymmetric umpolung reaction of imines to synthesize isoindolinones and tetrahydroisoquinolines
Catalytic asymmetric umpolung reaction of imines to synthesize isoindolinones and tetrahydroisoquinolines
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DOI：
10.1016/j.gresc.2021.01.001
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发表时间：
2021-01
期刊：
影响因子：
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通讯作者：
Zehuai Mou;Xia Zhang;D. Niu
中科院分区：
文献类型：
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作者：
Zehuai Mou;Xia Zhang;D. Niu
基于异吲哚啉酮和四氢异喹啉的环状支架包括广泛的生物活性分子的关键结构特征。本文报道了一种基于亚胺的烯丙基化反应合成手性异吲哚啉酮和四氢异喹啉的方法。产物含有游离N-H基团，其为进一步衍生化做好准备。
Isoindolinone- and tetrahydroisoquinoline-based cyclic scaffolds comprise the key, structural feature of a wide range of biologically active molecules. Here we report an, approach for the synthesis of chiral isoindolinones and tetrahydroisoquinolines based, on the umpolung allylation of imines. The products contain a free N–H group, which is, primed for further derivatization.