Integration of target analyses, non-target screening and effect-based monitoring to assess OMP related water quality changes in drinking water treatment
Integration of target analyses, non-target screening and effect-based monitoring to assess OMP related water quality changes in drinking water treatment
复制标题
DOI：
10.1016/j.scitotenv.2019.135779
复制
发表时间：
2020-02-25
影响因子：
9.8
通讯作者：
ter Laak, Thomas L.
中科院分区：
文献类型：
--
作者：
Brunner, Andrea M.;Bertelkamp, Cheryl;ter Laak, Thomas L.
化学品生产和使用的不断增加导致饮用水源中有机微污染物（OMP）的出现，因此需要在饮用水处理过程中去除它们。由于OMP的数量庞大，仅使用有针对性的化学分析进行监测不足以评估饮用水质量及其在处理过程中的变化。基于高分辨率质谱 (HRMS) 的非目标筛选 (NTS) 以及使用生物测定的基于效果的监测是有前途的监测工具，可用于更全面地评估水质和处理性能。在这里，我们制定了一项策略，整合来自化学目标分析、NTS 和生物测定的数据。我们将其应用于三个饮用水处理试点设施中 OMP 相关水质变化的评估。这些装置包括高级氧化工艺、超滤与反渗透相结合以及颗粒活性炭过滤。与饮用水行业相关的 OMP 被添加到这些设施处理的水中。对所有三个装置的样品进行了目标分析、NTS 和生物测定。筛选 NTS 数据以查找掺入化合物的预测和已知转化产物。同时，使用多变量分析方法评估 NTS 特征的趋势概况。通过将化学数据与基于生物效应的结果相结合，在优先排序过程中考虑了潜在毒性。三种分析方法的协同作用可以监测 OMP 和转化产物，以及化学品混合物的综合生物效应。通过对复杂数据的有效分析、可视化和解释，所制定的策略能够从多个角度评估水质和水处理的影响。仅通过这三种方法中的任何一种都无法获得此类信息。因此，所制定的战略为饮用水公司提供了综合水质评估的综合工具。 (C) 2019 年作者。由 Elsevier B.V. 出版
The ever-increasing production and use of chemicals lead to the occurrence of organic micro-pollutants (OMPs) in drinking water sources, and consequently the need for their removal during drinking water treatment Due to the sheer number of OMPs, monitoring using targeted chemical analyses alone is not sufficient to assess drinking water quality as well as changes thereof during treatment. High-resolution mass spectrometry (HRMS) based non-target screening (NTS) as well as effect-based monitoring using bioassays are promising monitoring tools for a more complete assessment of water quality and treatment performance. Here, we developed a strategy that integrates data from chemical target analyses, NTS and bioassays. We applied it to the assessment of OMP related water quality changes at three drinking water treatment pilot installations. These installations included advanced oxidation processes, ultrafiltration in combination with reverse osmosis, and granular activated carbon filtration. OMPs relevant for the drinking water sector were spiked into the water treated in these installations. Target analyses, NTS and bioassays were performed on samples from all three installations. The NTS data was screened for predicted and known transformation products of the spike-in compounds. In parallel, trend profiles of NTS features were evaluated using multivariate analysis methods. Through integration of the chemical data with the biological effect-based results potential toxicity was accounted for during prioritization. Together, the synergy of the three analytical methods allowed the monitoring of OMPs and transformation products, as well as the integrative biological effects of the mixture of chemicals. Through efficient analysis, visualization and interpretation of complex data, the developed strategy enabled to assess water quality and the impact of water treatment from multiple perspectives. Such information could not be obtained by any of the three methods alone. The developed strategy thereby provides drinking water companies with an integrative tool for comprehensive water quality assessment. (C) 2019 The Authors. Published by Elsevier B.V.