Relationship between Apelin/APJ Signaling, Oxidative Stress, and Diseases
Relationship between Apelin/APJ Signaling, Oxidative Stress, and Diseases
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DOI：
10.1155/2021/8866725
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发表时间：
2021-01
影响因子：
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通讯作者：
Shuangyu Lv;Yu Feng;Qiying Jiang;Xinrui Lv;Yanjie Yang
中科院分区：
文献类型：
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作者：
Shuangyu Lv;Yu Feng;Qiying Jiang;Xinrui Lv;Yanjie Yang
Apelin是一种肽激素，是G蛋白偶联受体的内源性配体，已被证明在人类和动物组织中广泛表达，如中枢神经系统和脂肪组织。近年来研究表明，apelin/APJ系统参与多种生理病理过程的调控，与心血管疾病、代谢紊乱、神经系统疾病、缺血再灌注损伤、衰老、子痫、耳聋、肿瘤等相关。这些疾病的发生发展与局部炎症反应密切相关。氧化应激是氧化和抗氧化之间的平衡被打破，大量产生活性氧，引起细胞或分子损伤，从而导致血管损伤和一系列炎症反应。因此，本文综述了近年来apelin/APJ与氧化应激及炎症相关疾病关系的研究进展，并强调其作为氧化应激相关炎症疾病的潜在治疗靶点。
Apelin, a peptide hormone, is an endogenous ligand for G protein-coupled receptor and has been shown to be widely expressed in human and animal tissues, such as the central nervous system and adipose tissue. Recent studies indicate that the apelin/APJ system is involved in the regulation of multiple physiological and pathological processes, and it is associated with cardiovascular diseases, metabolic disorders, neurological diseases, ischemia-reperfusion injury, aging, eclampsia, deafness, and tumors. The occurrence and development of these diseases are closely related to the local inflammatory response. Oxidative stress is that the balance between oxidation and antioxidant is broken, and reactive oxygen species are produced in large quantities, causing cell or molecular damage, which leads to vascular damage and a series of inflammatory reactions. Hence, this article reviewed recent advances in the relationship between apelin/APJ and oxidative stress, and inflammation-related diseases, and highlights them as potential therapeutic targets for oxidative stress-related inflammatory diseases.