Stage specific activity of synthetic antimalarial endoperoxides, N-89 and N-251, against Plasmodium falciparum.
Stage specific activity of synthetic antimalarial endoperoxides, N-89 and N-251, against Plasmodium falciparum.
复制标题
合成抗疟内过氧化物 N-89 和 N-251 针对恶性疟原虫的阶段比活性。
DOI：
10.1016/j.parint.2014.10.007
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
H.-S
中科院分区：
文献类型：
--
作者：
Morita;M.;Koyama;T.;Sanai;H.;Sato;K.;hiramoto;A.;Masuyama;A.;Nojima;M.;Wataya;Y. and Kim;H.-S
We have reported that two endoperoxides, N-89 and N-251, synthesized in 2001, possess potent antimalarial activities. Aiming at their eventual use for curing malaria in humans, we have been investigating various aspects of their antimalarial actions. Here we show that N-89 and N-251 inhibit the growth of Plasmodium falciparum within human erythrocytesin vitroat its lifecycle stage ‘trophozoite’ specifically. It is known that artemisinin compounds, which are currently used for curing malaria, have other stage-specificities. Therefore, it is likely that the antimalarial mechanism of N-89 and N-251 differs from those of artemisinin compounds. As malaria parasites resistant to artemisinin-based combination therapy are currently emerging in some tropical regions, N-89 and N-251 are candidates for overcoming these new problems.
影响因子：
7.3
作者：
Kim, HS;Nagai, Y;McCullough, KJ
通讯作者：
McCullough, KJ
合成抗疟药N-251的药代动力学研究
DOI：
--
发表时间：
2019
期刊：
影响因子：
--
作者：
Rena Isogawa;Kyung-Soo Chang;Akira Sato;Hye-Sook Kim
通讯作者：
Hye-Sook Kim