Identification of a limited T-cell receptor beta chain variable region repertoire associated with diabetes in the BB rat.
Identification of a limited T-cell receptor beta chain variable region repertoire associated with diabetes in the BB rat.
复制标题
鉴定与 BB 大鼠糖尿病相关的有限 T 细胞受体 β 链可变区库。
DOI：
10.1073/pnas.88.21.9888
复制
发表时间：
1991
影响因子：
11.1
通讯作者：
Bellgrau,D
中科院分区：
文献类型：
--
作者：
Gold,DP;Bellgrau,D
由于产生胰岛素的β-胰岛细胞的T细胞依赖性破坏，易患糖尿病的BB大鼠自发发展为1型糖尿病。许多T细胞异常，包括淋巴细胞减少症、细胞介导的对同种异体抗原的反应性差以及RT 6 + T细胞亚群的缺乏与疾病易感性相关。我们以前的研究表明胸腺抗原提呈细胞影响疾病的可能性和对同种异体抗原的反应性。由于这种细胞类型也被称为影响T细胞受体表达发育中的胸腺细胞，我们研究了胸腺和外周T细胞受体β链可变区库在糖尿病易感和糖尿病耐药大鼠。我们的研究结果表明，易受糖尿病诱导的动物具有特征性和有限的外周β链可变区库，其与胸腺中表达的明显不同。
Diabetes-prone BB rats spontaneously develop type 1 diabetes due to a T-cell-dependent destruction of insulin-producing beta-islet cells. A number of T-cell abnormalities including lymphopenia, poor cell-mediated responsiveness to alloantigen, and an absence of an RT6+ T-cell subset are associated with disease susceptibility. Our previous studies have implicated the thymic antigen-presenting cell in influencing disease potential and responsiveness to alloantigen. Since this cell type is also known to influence T-cell receptor expression in developing thymocytes, we examined the thymic and peripheral T-cell receptor beta chain variable region repertoire in diabetes-prone and diabetes-resistant rats. Our findings indicate that animals susceptible to diabetes induction have a characteristic and limited peripheral beta chain variable region repertoire that differs markedly from that expressed in the thymus.