Differential regulation of the AP-1 family members by UV irradiation in vitro and in vivo
Differential regulation of the AP-1 family members by UV irradiation in vitro and in vivo
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DOI：
10.1016/s0898-6568(97)00100-9
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发表时间：
1998-03-01
影响因子：
4.8
通讯作者：
Punnonen, K
中科院分区：
文献类型：
--
作者：
Isoherranen, K;Westermarck, J;Punnonen, K
We have examined the effect of UVB and solar-simulated irradiation on the expression of the AP-1 family of transcription factors and the cytokine IL-6 both in cell cultures and in human skin in vivo. UVB irradiation potently induced c-jun, junB and c-fos mRNA levels in vitro in HaCaT cells. IL-G mRNA was induced in response to UVB irradiation 2-3 h later than c-jun, junB and c-Jos mRNAs. In human skin in vivo, solar-simulated irradiation induced transiently junB expression. Genistein, a tyrosine kinase inhibitor, augmented the induction of c-jun and junB by UVB irradiation in HaCaT cells. The results of this study provide evidence that in addition to c-jun and c-Jos, junB is also an essential component of the human UV-response. This study also suggests that UVB irradiation regulates the AP-1 family by several mechanisms and that the signalling mechanisms of UVB irradiation are considerably different from the ones used by UVC irradiation. (C) 1998 Elsevier Science Inc.
