LINC00309 is associated with short disease-free survival in breast cancer
LINC00309 is associated with short disease-free survival in breast cancer
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LINC00309 与乳腺癌的短无病生存期相关
DOI：
10.1186/s12935-019-0887-x
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发表时间：
2019-08-07
影响因子：
5.8
通讯作者：
Wu, Jiong
中科院分区：
文献类型：
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作者：
Huang, Sheng;Chi, Yayun;Wu, Jiong
研究背景长链非编码RNA在乳腺癌中起重要作用。即使辅助激素治疗，雌激素受体阳性乳腺癌患者也可能出现复发和远处转移。我们调查了一种新的长非编码RNA LINC 00309的表达是否可以预测乳腺癌的结果，特别是对乳腺癌受体阳性patients.MethodsThis回顾性研究收集了290例乳腺癌患者，其中161例乳腺癌受体阳性。进行qPCR以检测LINC 00309的表达。采用Kaplan-Meier和考克斯风险比例模型分析LINC 00309在乳腺癌中的作用（HR= 2.127; 95% CI 1.074-4.212; p= 0.030），并与较短的无病生存期（p= 0.027）相关，特别是在乳腺癌阳性患者中（p= 0.001）。此外，LINC 00309高表达与选择性雌激素受体调节剂相关激素治疗（p= 0.025）和芳香酶抑制剂相关激素治疗（p= 0.048）中较短的无病生存期相关。此外，LINC 00309是乳腺癌受体阳性患者无病生存期较差的独立预测因子，（HR= 4.505; 95% CI 1.722-11.785;p= 0.002）和多变量（HR= 4.159; 95%CI 1.537-11.251;p= 0.005）分析。结论在乳腺癌中，Linc 00309与预后不良显著相关，可能代表一种新的预后标志物。
BackgroundLong non-coding RNAs play an important role in breast cancer. Even with adjuvant hormone therapy, patients with estrogen receptor positive breast cancer can present with recurrences and distant metastases. We investigated whether the expression of a novel long non-coding RNA LINC00309 can predict the outcome of breast cancer, especially for hormone-receptor positive patients.MethodsThis retrospective study collected 290 breast cancer patients including 161 patients with hormone-positive. qPCR was performed to detect the expression of LINC00309. Kaplan–Meier and Cox risk proportion model were applied to disclose the function of LINC00309 for breast cancer prognosis.ResultsLINC00309 high expression was an independent predictor for worse disease-free survival (HR= 2.127; 95% CI 1.074–4.212;p= 0.030) and associated with a shorter disease-free survival (p= 0.027), especially in hormone-positive breast cancer patients (p= 0.001). Also LINC00309 high expression was associated with a shorter disease-free survival both in selective estrogen receptor modulator related hormone therapy (p= 0.025) and aromatase inhibitors related hormone therapy (p= 0.048). Moreover, LINC00309 was an independent predictor of worse disease-free survival in hormone-receptor positive breast cancer patients on univariate (HR= 4.505; 95% CI 1.722–11.785;p= 0.002) and multivariate (HR= 4.159; 95% CI 1.537–11.251;p= 0.005) analyses.ConclusionIn breast cancer, Linc00309 is significantly associated with poor prognosis and may represent a new marker of prognosis.