A DEMONSTRATION THAT 5-HYDROXYTRYPTAMINE ADMINISTERED PERIPHERALLY CAN AFFECT SEXUAL-BEHAVIOR IN MALE-RATS
A DEMONSTRATION THAT 5-HYDROXYTRYPTAMINE ADMINISTERED PERIPHERALLY CAN AFFECT SEXUAL-BEHAVIOR IN MALE-RATS
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DOI：
10.1016/0024-3205(82)90724-x
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发表时间：
1982-01-01
期刊：
影响因子：
6.1
通讯作者：
TORREJON, J
中科院分区：
文献类型：
--
作者：
GONZALES, G;MENDOZA, L;TORREJON, J
在雄性大鼠中，s.c.连续7天注射20 mg/kg B.W. [body 5-羟色胺肌酸酐硫酸盐（5-HT）对大鼠的性行为有明显的抑制作用。5-HT处理组大鼠的射精潜伏期和勃起潜伏期增加，而5-HT处理组大鼠的射精潜伏期与对照组大鼠相似。5-HT处理组大鼠的爬出频率和传入频率均降低。5-HT处理的大鼠平均插入间隔（MIII）和射精后间隔延长。提示外周5-HT在调节雄性大鼠性行为中的作用。
In the male rat, s.c. injections for 7 days of 20 mg/kg B.W.[body wt]/day of 5-hydroxytryptamine creatinine sulfate (5-HT), caused remarkable inhibitory effects on sexual behavior. The mount and intromission latencies were increased in rats treated with 5-HT, whereas ejaculation latency in the few rats treated with 5-HT that it achieved, was similar to that obtained in control rats. The mount and intromission frequencies were decreased in the rats treated with 5-HT. The mean inter-intromission interval (MIII) and post-ejaculatory interval were prolonged in rats treated with 5-HT. The role of peripheral 5-HT in regulating sexual behavior of male rats is indicated.