Intermolecular Decarboxylative Direct C-3 Arylation of Indoles with Benzoic Acids
Intermolecular Decarboxylative Direct C-3 Arylation of Indoles with Benzoic Acids
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DOI：
10.1021/ol902304n
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发表时间：
2009-12-03
期刊：
影响因子：
5.2
通讯作者：
Larrosa, Igor
中科院分区：
文献类型：
--
作者：
Cornella, Josep;Lu, Pengfei;Larrosa, Igor
钯催化的吲哚的C-H活化和银催化的邻位取代苯甲酸的脱羧C-C活化协同作用合成了仅在C-3位置芳基化的吲哚。这种新颖的脱羧C-H基化方法与两个偶联伙伴中的供电子和吸电子取代基兼容。
A palladium catalyzed C-H activation of indoles and a silver catalyzed decarboxylative C-C activation of ortho substituted benzoic acids are synergistically combined to synthesize indoles arylated exclusively in the C-3 position. This novel decarboxylative C-H arylation methodology is compatible with electron-donating and -withdrawing substituents in both coupling partners.