RATE OF REINFECTION WITH INTESTINAL NEMATODES AFTER TREATMENT OF CHILDREN WITH MEBENDAZOLE OR ALBENDAZOLE IN A HIGHLY ENDEMIC AREA
RATE OF REINFECTION WITH INTESTINAL NEMATODES AFTER TREATMENT OF CHILDREN WITH MEBENDAZOLE OR ALBENDAZOLE IN A HIGHLY ENDEMIC AREA
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DOI：
10.1016/0035-9203(95)90101-9
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发表时间：
1995-09-01
影响因子：
2.2
通讯作者：
SAVIOLI, L
中科院分区：
文献类型：
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作者：
ALBONICO, M;SMITH, PG;SAVIOLI, L
在坦桑尼亚奔巴岛的学龄儿童中进行的一项随机试验中，比较了阿苯达唑和甲苯达唑治疗肠道线虫感染3周后的疗效。在治疗后3周、4个月和6个月，对每次观察的731名儿童的卵子计数进行了比较。治疗后21天，某些线虫的疗效差异明显，但治疗后4个月这些差异不再明显，6个月时感染强度与治疗前水平相似。这些研究结果表明，在这一高度流行的地区，每4个月对学童进行一次治疗可能是必要的，以便对肠道线虫感染的强度产生足以降低发病率的影响。
The comparative efficacy of albendazole and mebendazole in the treatment of intestinal nematode infections were compared 3 weeks after treatment in a randomized trial among schoolchildren on Pemba Island, Tanzania. Egg counts were compared 3 weeks, 4 months and 6 months after treatment of 731 children seen on each occasion. Differences in the efficacies were apparent with some nematodes 21 d after treatment, but these were no longer apparent 4 months after treatment, and by 6 months intensities of infection were similar to pre-treatment levels. These findings suggest that treatment of schoolchildren every 4 months may be necessary in this highly endemic area in order to have an impact on the intensity of intestinal nematode infections sufficient to be likely to reduce morbidity.