Therapeutic Targeting of Immune Cell Autophagy in Multiple Sclerosis: Russian Roulette or Silver Bullet?
Therapeutic Targeting of Immune Cell Autophagy in Multiple Sclerosis: Russian Roulette or Silver Bullet?
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DOI：
10.3389/fimmu.2021.724108
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发表时间：
2021
影响因子：
7.3
通讯作者：
Van Kaer L
中科院分区：
文献类型：
--
作者：
Yang G;Van Kaer L
多发性硬化症（MS）是中枢神经系统（CNS）的慢性炎症性疾病，其中免疫系统损害从神经元突出的神经纤维周围的保护性绝缘。MS的病理学标志是CNS内多个区域的髓鞘损失伴随炎症，导致认知功能丧失，最终导致瘫痪。MS的最新研究集中在自噬，一种细胞自食过程，作为MS治疗的潜在目标。在这里，我们回顾了免疫细胞自噬对实验性自身免疫性脑脊髓炎（EAE）的发病机制的贡献，MS的原型动物模型。更好地了解自噬在不同免疫细胞中对EAE的作用可能会为MS和其他自身免疫性和炎症性疾病的新治疗方法的发展提供信息。
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) in which the immune system damages the protective insulation surrounding nerve fibers that project from neurons. The pathological hallmark of MS is multiple areas of myelin loss accompanied by inflammation within the CNS, resulting in loss of cognitive function that ultimately leads to paralysis. Recent studies in MS have focused on autophagy, a cellular self-eating process, as a potential target for MS treatment. Here, we review the contribution of immune cell autophagy to the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the prototypic animal model of MS. A better understanding of the role of autophagy in different immune cells to EAE might inform the development of novel therapeutic approaches in MS and other autoimmune and inflammatory diseases.