Interventions for seropositive injectors -: Research and evaluation -: An integrated behavioral intervention with HIV-positive injection drug users to address medical care, adherence, and risk reduction
Interventions for seropositive injectors -: Research and evaluation -: An integrated behavioral intervention with HIV-positive injection drug users to address medical care, adherence, and risk reduction
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DOI：
10.1097/01.qai.0000140609.44016.c4
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发表时间：
2004-10-01
影响因子：
3.6
通讯作者：
Latkin, CA
中科院分区：
文献类型：
--
作者：
Purcell, DW;Metsch, LR;Latkin, CA
背景：迫切需要采取行为干预措施，以解决艾滋病毒血清阳性注射吸毒者（IDUs）复杂的医疗和艾滋病毒风险降低需求。我们描述了针对血清阳性注射者的干预研究与评估（INSPIRE）的发展，这是一项针对hiv阳性注射者的综合干预的随机对照试验，以及基线样本的特征。方法：从美国4个城市的社区环境中招募hiv阳性注射吸毒者。在完成基线评估后，参加第一次会议的参与者被随机分配到(1)10次同伴指导干预，旨在提高艾滋病毒护理的利用，提高对艾滋病毒药物的依从性，并降低性和注射风险；或(2)8次录像带控制。正在进行为期12个月的定期随访。结果：共有1161名hiv阳性注射吸毒者完成了基线评估，其中966名（83%）被随机化。所有随访期间的留存率都大于80%。大约79%的基线参与者报告最近就诊，49%正在接受高活性抗逆转录病毒治疗，19%的病毒载量无法检测到。注射和非注射物质的使用很普遍，25%以上的参与者报告了性风险和注射风险。结论：有必要对hiv阳性注射吸毒者进行综合干预，这些数据表明这种方法是可接受的。
Background: Behavioral interventions to address the complex medical and HIV risk reduction needs of HIV-seropositive (HIV-positive) injection drug users (IDUs) are urgently needed. We describe the development of Interventions for Seropositive Injectors-Research and Evaluation (INSPIRE), a randomized controlled trial of an integrated intervention for HIV-positive IDUs, and the characteristics of the baseline sample.Methods: HIV-positive IDUs were recruited from community settings in 4 US cities. After completing a baseline assessment, participants who attended the first session were randomly assigned to (1) a 10-session peer mentoring intervention designed to improve utilization of HIV care, to improve adherence to HIV medications, and to reduce sexual and injection risk or (2) an 8-session videotape control. Periodic follow-up for 12 months is ongoing.Results: A total of 1161 HIV-positive IDUs completed the baseline assessment, and 966 (83%) were randomized. Retention rates are greater than 80% for all follow-up periods. Approximately 79% of baseline participants reported a recent medical visit, 49% were taking highly active antiretroviral therapy, and 19% had an undetectable viral load. Use of injection and noninjection substances was prevalent, and sexual and injection risks were each reported by more than 25% of participants.Conclusion: There is a need for an integrated intervention for HIV-positive IDUs, and these data show the acceptability of such an approach.