Factors influencing the occurrence of active cytomegalovirus (CMV) infections after organ transplantation
Factors influencing the occurrence of active cytomegalovirus (CMV) infections after organ transplantation
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器官移植后发生活动性巨细胞病毒（CMV）感染的影响因素
DOI：
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发表时间：
1993
影响因子：
4.6
通讯作者：
G. Gast
中科院分区：
文献类型：
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作者：
G. Boland;R. Hené;C. Ververs;M. A. M. D. Haan;G. Gast
本研究分析了影响器官移植术后活动性巨细胞病毒感染发生的几个因素。为此，对105例巨细胞病毒阳性或供者巨细胞病毒阳性的心、肾、肺移植受者，通过抗原血症、培养和活动性巨细胞病毒感染进行密切监测。CMV血清学和淋巴细胞对CMV的增殖反应。进行单因素和多因素回归分析。作为移植前的危险因素，分析了受者和供者之间的人类白细胞抗原的类型和数目，以及受者和供者之间的巨细胞病毒血清学。一项新的发现是，HLA-B7阳性供者尤其容易患上活动性巨细胞病毒感染(P=0.03)和巨细胞病毒病(P=0.03)。这不是因为这些患者接受更多的排斥治疗。移植后发生活动性CMV感染的危险因素是TX后未检测到对CMV的细胞免疫(P<；0.01)，以及OKT3或ATG治疗的排斥反应(P=0.05)。在CMV+受者中，高水平的抗CMV抗体并不能预防CMV活动性感染或CMV病的发生。
In this study, several factors influencing the occurrence of active CMV infection after organ transplantation (Tx) arc analysed. For this purpose, 105 heart, kidney and lung transplant recipients who were CMV‐positive or had a CMV‐positive donor, were closely monitored for active CMV infection by antigenaemia, cultures. CMV serology and lymphocyte proliferation (LP) to CMV. Univariate and multivariate regression analysis were performed. As pretransplant risk factors the HLA‐type and numbers of HLA mismatches between recipients and their donors, and the CMV serology of the recipient and donor were analysed. A new finding was that recipients of donors positive for HLA‐B7 were especially at risk for developing active CMV infection (P = 0.03) and CMV disease (P= 0.03). This was not due to increased rejection treatment in these patients. Post‐transplant risk factors for development of active CMV infection were absence of detectable cellular immunity to CMV (lymphocyte proliferation) after Tx (P<0.01) and rejection treatment with OKT3 or ATG (P = 0.05). High levels of IgG anti‐CMV did not prevent occurrence of active CMV infection or CMV disease in the CMV+ recipients.
CTL 粘附和抗原识别是人类 CTL-靶细胞相互作用中的离散步骤。
DOI：
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发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Mentzer,SJ;Smith,BR;Barbosa,JA;Crimmins,MA;Herrmann,SH;Burakoff,SJ
通讯作者：
Burakoff,SJ
巨细胞病毒感染和 HLA 匹配对肾移植结果的影响。
影响因子：
0.9
作者：
Waltzer,WC;Arnold,AN;Anaise,D;Hurley,S;Raisbeck,A;Egelandsdsdal,B;Pullis,C;Rapaport,FT
通讯作者：
Rapaport,FT
因白血病而进行 T 细胞耗尽的 HLA 异种骨髓移植受者的移植物排斥反应。
影响因子：
6.2
作者：
Kernan,NA;Flomenberg,N;Dupont,B;O'Reilly,RJ
通讯作者：
O'Reilly,RJ