Antihyperglycemic effects of stevioside in type 2 diabetic subjects
Antihyperglycemic effects of stevioside in type 2 diabetic subjects
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DOI：
10.1016/j.metabol.2003.07.013
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发表时间：
2004-01-01
影响因子：
9.8
通讯作者：
Hermansen, K
中科院分区：
文献类型：
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作者：
Gregersen, S;Jeppesen, PB;Hermansen, K
甜菊苷存在于植物甜叶菊Bertoni（SrB）中。SrB的提取物已被用于治疗糖尿病，例如，在巴西，虽然对葡萄糖代谢的积极作用尚未明确证明。我们研究了甜菊糖对2型糖尿病患者的急性影响。我们假设在试验餐中补充甜菊苷会导致餐后血糖降低。12例2型糖尿病患者被纳入一项急性、配对交叉研究。标准测试膳食补充有1g甜菊苷或1g玉米淀粉（对照）。在摄入试验餐前30分钟和摄入试验餐后240分钟抽取血样。与对照组相比，甜菊苷使葡萄糖反应曲线下的增量面积减少了18%（P = 0.013）。与对照相比，甜菊苷使胰岛素生成指数（AUC（i，胰岛素）/AUC（i，葡萄糖））增加约40%（P < .001）。甜菊苷倾向于降低胰高血糖素水平，而它没有显著改变胰岛素、胰高血糖素样肽1和葡萄糖依赖性促胰岛素多肽曲线下面积。总之，甜菊苷降低2型糖尿病患者的餐后血糖水平，表明对葡萄糖代谢的有益作用。2型糖尿病的治疗方法有哪些？(C)2004年爱思唯尔公司All rights reserved.
Stevioside is present in the plant Stevia rebaudiana Bertoni (SrB). Extracts of SrB have been used for the treatment of diabetes in, for example, Brazil, although a positive effect on glucose metabolism has not been unequivocally demonstrated. We studied the acute effects of stevioside in type 2 diabetic patients. We hypothesize that supplementation with stevioside to a test meal causes a reduction in postprandial blood glucose. Twelve type 2 diabetic patients were included in an acute, paired cross-over study. A standard test meal was supplemented with either 1 g of stevioside or 1 g of maize starch (control). Blood samples were drawn at 30 minutes before and for 240 minutes after ingestion of the test meal. Compared to control, stevioside reduced the incremental area under the glucose response curve by 18% (P = .013). The insulinogenic index (AUC(i,insulin)/AUC(i,glucose)) was increased by approximately 40% by stevioside compared to control (P < .001). Stevioside tended to decrease glucagon levels, while it did not significantly alter the area under the insulin, glucagon-like peptide 1, and glucose-dependent insulinotropic polypeptide curves. In conclusion, stevioside reduces postprandial blood glucose levels in type 2 diabetic patients, indicating beneficial effects on the glucose metabolism. Stevioside may be advantageous in the treatment of type 2 diabetes. (C) 2004 Elsevier Inc. All rights reserved.