SYNDROME PRODUCED BY LESIONS OF THE AMYGDALA IN MONKEYS (MACACA, MULATTA)
SYNDROME PRODUCED BY LESIONS OF THE AMYGDALA IN MONKEYS (MACACA, MULATTA)
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DOI：
10.1037/h0077848
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
PASSINGHAM, RE
中科院分区：
文献类型：
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作者：
AGGLETON, JP;PASSINGHAM, RE
行为影响杏仁核次全病变进行了调查，分离后看到的杏仁核全切除术的一些异常。十二只猴子[M. mulatta]接受双侧立体定位病变，病变中心位于基底外侧杏仁核、外侧杏仁核、背侧杏仁核或邻近外侧杏仁核的颞部白色物质。将这些猴子与其他具有控制操作的猴子进行比较。对照组猴子接受全杏仁核损伤（AMX）。AMX猴表现出典型的杏仁核综合征的情绪减退，食肉，食粪和过度探索。杏仁核次全损伤的猴子不会吃肉或粪便，尽管它们比对照组的猴子更愿意研究无生命的物体。虽然观察到轻微的变化，影响，极端的情绪变化后，看到杏仁核全切除术后，只发现在猴子与最大的次全病变。只有低情感动物表现出赤字在学习连续逆转的对象歧视。这种密切的联系表明，情绪减退和连续逆转缺陷都是由相同的潜在功能障碍引起的。
Behavioral effects of subtotal amygdaloid lesions were investigated to dissociate some of the abnormalities seen after total amygdalectomy. Twelve monkeys [M. mulatta] received bilateral stereotaxic lesions centered in the basolateral amygdala, lateral amygdala, dorsal amygdala or the temporal white matter lying adjacent to the lateral amygdala. The monkeys were compared with others with control operations. The control monkeys than received total amygdaloid lesions (AMX). AMX monkeys exhibited the typical amygdaloid syndrome of hypoemotionality, meat eating, coprophagia and excessive exploration. Monkeys with subtotal amygdaloid lesions would not eat meat or feces, though they were more willing than control monkeys to investigate inanimate objects. Although minor changes in affect were observed, extreme emotional changes seen after total amygdalectomy were found only in the monkey with the largest subtotal lesion. Only hypoemotional animals showed a deficit in learning successive reversals of an object discrimination. This close association suggests that both the hypoemotionality and the successive reversal deficit arise from the same underlying dysfunction.