Highly sensitive muscarinic receptors in the cerebellum are coupled to prostaglandin formation.
Highly sensitive muscarinic receptors in the cerebellum are coupled to prostaglandin formation.
复制标题
小脑中高度敏感的毒蕈碱受体与前列腺素的形成偶联。
DOI：
10.1016/0006-291x(87)90783-2
复制
发表时间：
1987
影响因子：
3.1
通讯作者：
Hokin,LE
中科院分区：
文献类型：
--
作者：
Reichman,M;Nen,W;Hokin,LE
There have been relatively few studies on the effects of neurotransmitters on the synthesis of prostaglandins in the brain. We report here that acetylcholine is very effective in stimulating prostaglandin synthesis in cerebellar cortex slices incubatedin vitro, i.e., 5 μM acetylcholine increased prostaglandin levels up to 3-fold over control levels. The response was saturable and dose-dependent over the range of 0.1–5 μM acetylcholine.Atropine, at a concentration of 50 nM, abolished the response. The results indicate that high-affinity muscarinic receptors in the cerebellum are coupled to prostaglandin formation. Potassium-induced depolarization or incubation with 0.1 mM histamine also significantly increased prostaglandin formation. These findings provide support for the notion that certain neurotransmitters can modulate prostaglandin levels in the mammalian brain.
