Magnitude of cognitive dysfunction in adults with type 2 diabetes: a meta-analysis of six cognitive domains and the most frequently reported neuropsychological tests within domains.
Magnitude of cognitive dysfunction in adults with type 2 diabetes: a meta-analysis of six cognitive domains and the most frequently reported neuropsychological tests within domains.
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DOI：
10.1017/s1355617713001483
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发表时间：
2014-03
影响因子：
2.6
通讯作者：
Hill-Briggs, Felicia
中科院分区：
文献类型：
--
作者：
Palta, Priya;Schneider, Andrea L. C.;Biessels, Geert Jan;Touradji, Pegah;Hill-Briggs, Felicia
关键词：
目的是根据系统评价和荟萃分析的首选报告项目（PRISMA）标准进行荟萃分析，以确定2型糖尿病成人认知功能障碍相对于非糖尿病对照的效应量（Cohen’s d），并获得领域内最常报道的神经心理学测试的效应量。24项研究，共计26137例患者（n = 3351例糖尿病患者）符合研究纳入标准。在六个领域中的五个领域获得了小到中等的效应大小：运动功能（3项研究，n = 2374; d = - 0.36）、执行功能（12项研究，n = 1784; d = - 0.33）、处理速度（16项研究，n = 3076; d = - 0.33）、言语记忆（15项研究，n = 4,608; d = - 0.28）和视觉记忆（6项研究，n = 1754; d = - 0.26）。注意/集中的效应值最小（14项研究，n = 23,143; d = - 0.19）。以下测试显示了糖尿病样本中最显著的表现下降：沟槽式Pegboard（惯用手）（d = - 0.60）、Rey听觉语言学习测试（立即）（d = - 0.40）、Trails B （d = - 0.39）、Rey- osterreith复杂图形（延迟）（d = - 0.38）、Trails A （d = - 0.34）和Stroop Part I （d = - 0.28）。本研究为未来的流行病学和临床糖尿病研究提供了效应量，以检查认知功能，并帮助选择神经心理学测试。
The objectives were to conduct a meta-analysis in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards to determine effect sizes (Cohen’s d) for cognitive dysfunction in adults with type 2 diabetes, relative to nondiabetic controls, and to obtain effect sizes for the most commonly reported neuropsychological tests within domains. Twenty-four studies, totaling 26,137 patients (n = 3351 with diabetes), met study inclusion criteria. Small to moderate effect sizes were obtained for five of six domains: motor function (3 studies, n = 2374; d = −0.36), executive function (12 studies, n = 1784; d = −0.33), processing speed (16 studies, n = 3076; d = −0.33), verbal memory (15 studies, n = 4,608; d = −0.28), and visual memory (6 studies, n = 1754; d = −0.26). Effect size was smallest for attention/concentration (14 studies, n = 23,143; d = −0.19). The following tests demonstrated the most notable performance decrements in diabetes samples: Grooved Pegboard (dominant hand) (d = −0.60), Rey Auditory Verbal Learning Test (immediate) (d = −0.40), Trails B (d = −0.39), Rey-Osterreith Complex Figure (delayed) (d = −0.38), Trails A (d = −0.34), and Stroop Part I (d = −0.28). This study provides effect sizes to power future epidemiological and clinical diabetes research studies examining cognitive function and to help inform the selection of neuropsychological tests.