Inhibition of B lymphocyte activation by interaction with Fc receptors.
Inhibition of B lymphocyte activation by interaction with Fc receptors.
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通过与 Fc 受体相互作用抑制 B 淋巴细胞活化。
DOI：
10.3109/08820137609033860
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
P. Henkart
中科院分区：
文献类型：
--
作者：
J. Ryan;P. Henkart
许多早期的研究表明，特异性抗体在免疫应答中起抑制作用。发现这种抑制活性依赖于体内和体外所用抗体的完整Fc部分。因此，淋巴细胞Fc受体在调节免疫应答中的作用被提出。然而，与Fc受体结合的可溶性抗原-抗体复合物似乎不抑制B细胞活化。最近的实验表明，固定在表面上的抗原抗体复合物显著抑制LPS诱导的B细胞有丝分裂和多克隆抗体的合成。人们已经考虑了Fc受体介导的抑制B细胞活化的机制，并提出了一个模型来解释其中的许多发现并允许抗原特异性抑制。
Much early work indicated that specific antibody can play an inhibitory role in the immune response. This inhibitory activity was found to be dependent on an intact Fc portion of the antibody used, both in vivo and in vitro. Thus a role for lymphocyte Fc receptors in regulations of the immune response was suggested. However, soluble antigen-antibody complexes, which bind to Fc receptors, do not appear to inhibit B cell activation. Recent experiments have demonstrated that antigen-antibody complexes immobilized on a surface strikingly inhibit LPS induced B cell mitogenesis and polyclonal antibody synthesis. Mechanisms for Fc receptor-mediated inhibition of B cell activation have been considered, and a model proposed to explain many of these findings as well as allow for antigen specific inhibition.