The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
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DOI：
10.1073/pnas.0705894104
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发表时间：
2007-10-23
影响因子：
11.1
通讯作者：
Hutton, John C.
中科院分区：
文献类型：
--
作者：
Wenzlau, Janet M.;Juhl, Kirstine;Hutton, John C.
1型糖尿病(T1D)是通过自身免疫作用于胰腺13细胞中表达的一系列不同但有限的分子而导致胰岛质量进行性丧失的结果。识别这些分子靶点有助于深入了解致病过程、诊断分析和潜在的治疗药物。从人和啮齿动物胰腺和胰岛细胞的微阵列表达谱中鉴定自身抗原候选，并用新发的T1D和糖尿病前期血清进行放射免疫沉淀试验筛选。一个高排名的候选基因，锌转运蛋白ZnT8(SIc30A8)，在60%-80%的新发T1D患者中是自身抗体的靶标，与
Type 1 diabetes (T1D) results from progressive loss of pancreatic islet mass through autoimmunity targeted at a diverse, yet limited, series of molecules that are expressed in the pancreatic 13 cell. Identification of these molecular targets provides insight into the pathogenic process, diagnostic assays, and potential therapeutic agents. Autoantigen candidates were identified from microarray expression profiling of human and rodent pancreas and islet cells and screened with radioimmunoprecipitation assays using newonset T1D and prediabetic sera. A high-ranking candidate, the zinc transporter ZnT8 (SIc30A8), was targeted by autoantibodies in 60-80% of new-onset T1D compared with