Childhood Disadvantage Moderates Late Midlife Default Mode Network Cortical Microstructure and Visual Memory Association.
Childhood Disadvantage Moderates Late Midlife Default Mode Network Cortical Microstructure and Visual Memory Association.
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童年劣势调节中年晚期默认模式网络皮质微观结构和视觉记忆关联。
DOI：
10.1093/gerona/glad114
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Krem
中科院分区：
文献类型：
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作者：
Tang,Rongxiang;Elman,JeremyA;Dale,AndersM;Dorros,StephenM;Eyler,LisaT;Fennema-Notestine,Christine;Gustavson,DanielE;HaglerJr,DonaldJ;Lyons,MichaelJ;Panizzon,MatthewS;Puckett,OliviaK;Reynolds,ChandraA;Franz,CarolE;Krem
童年不利条件是认知和大脑衰老的重要危险因素。童年劣势与中年后期较差的情景记忆以及默认模式网络（DMN）的功能和结构异常有关。尽管与年龄相关的DMN变化与老年人情景记忆衰退有关，但尚不清楚童年时期的不利条件是否会对老年早期大脑认知关系产生持久影响。这里，在DMN中，我们检查了其皮层微观结构完整性（结构脆弱性的早期标志，增加了未来认知能力下降和神经退行性变的风险）是否与56-66岁成人的情景记忆有关，以及儿童时期的劣势是否减缓了这种联系。方法采用扩散磁共振成像获得的平均扩散率（MD）测量350例社区居住男性的显微结构完整性。我们检查了与DMN MD相关的视觉和言语情景记忆，并根据父母的教育程度和职业将参与者分为弱势和非弱势群体。结果较高的DMN MD与较差的视觉记忆相关，而与较差的言语记忆无关（β = - 0.11,p= 0.040 vs β = - 0.04,p= .535）。这种关联被童年不利条件所缓和，并且仅在不利条件组中显著（β = - 0.26,p= 0.002 vs β = - 0.00,p= 0.957）。结论认知正常成人DMN皮层微结构完整性变慢可能在衰老过程中较早反映视觉记忆脆弱性。经历过童年不利条件的个体比面对低皮层微观结构完整性的非不利条件的个体更容易出现与皮层微观结构相关的视觉记忆功能障碍。
BackgroundChildhood disadvantage is a prominent risk factor for cognitive and brain aging. Childhood disadvantage is associated with poorer episodic memory in late midlife and functional and structural brain abnormalities in the default mode network (DMN). Although age-related changes in DMN are associated with episodic memory declines in older adults, it remains unclear if childhood disadvantage has an enduring impact on this later-life brain–cognition relationship earlier in the aging process. Here, within the DMN, we examined whether its cortical microstructural integrity—an early marker of structural vulnerability that increases the risk for future cognitive decline and neurodegeneration—is associated with episodic memory in adults at ages 56–66, and whether childhood disadvantage moderates this association.MethodsCortical mean diffusivity (MD) obtained from diffusion magnetic resonance imaging was used to measure microstructural integrity in 350 community-dwelling men. We examined both visual and verbal episodic memory in relation to DMN MD and divided participants into disadvantaged and nondisadvantaged groups based on parental education and occupation.ResultsHigher DMN MD was associated with poorer visual memory but not verbal memory (β = −0.11,p= .040 vs β = −0.04,p= .535). This association was moderated by childhood disadvantage and was significant only in the disadvantaged group (β = −0.26,p= .002 vs β = −0.00,p= .957).ConclusionsLower DMN cortical microstructural integrity may reflect visual memory vulnerability in cognitively normal adults earlier in the aging process. Individuals who experienced childhood disadvantage manifested greater vulnerability to cortical microstructure-related visual memory dysfunction than their nondisadvantaged counterparts who exhibited resilience in the face of low cortical microstructural integrity.