Transforming growth factor beta-induced connective tissue growth factor and chronic allograft rejection
Transforming growth factor beta-induced connective tissue growth factor and chronic allograft rejection
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DOI：
10.1111/j.1600-6143.2006.01292.x
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发表时间：
2006-05-01
影响因子：
8.8
通讯作者：
Bishop, DK
中科院分区：
文献类型：
--
作者：
Csencsits, K;Wood, SC;Bishop, DK
同种异体移植物功能的晚期丧失主要归因于慢性排斥（CR）。 CR 没有有效的治疗方法，并且该疾病的根本原因尚不清楚。这项研究比较了接受抗 CD4 治疗并出现 CR 或抗 CD40L 治疗但未出现 CR 的小鼠心脏同种异体移植物中发生的事件。 TGFO 诱导的 TGFP 和结缔组织生长因子 (CTGF) 在具有 CR 的移植物中表达，但在不具有 CR 的移植物中不表达。抗CD40L处理的受体中同种异体移植物的TGFO转染导致CTGF表达和CR。然而，同基因移植物的 TGFP 转染不会导致 CTGF 表达或 CR。这些数据表明单独的TGFP不足以诱导CR并且需要CTGF。此外，TGFP诱导CTGF需要抗原刺激。因此，CTGF可以作为CR的治疗靶点。
Late loss of allograft function is primarily attributed to chronic rejection (CR). There are no effective treatments for CR and the underlying cause of the disease is unknown. This study compared events that occurred within cardiac allografts placed in mice that received either anti-CD4 therapy and develop CR or anti-CD40L therapy and do not develop CR. Both TGFP and connective tissue growth factor (CTGF), which is induced by TGFO, were expressed in grafts with CR but were not expressed in grafts without CR. TGFO transfection of allografts in anti-CD40L-treated recipients resulted in CTGF expression and CR. However, TGFP transfection of syngeneic grafts did not result in CTGF expression or CR. These data indicate that TGFP alone is insufficient to induce CR and that CTGF is required. Further, antigenic stimulation is required for TGFP induction of CTGF. Thus, CTGF may serve as a therapeutic target for CR.