Synthesis and biological response of casein-based silica nano-composite film for drug delivery system.
Synthesis and biological response of casein-based silica nano-composite film for drug delivery system.
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DOI：
10.1016/j.colsurfb.2013.06.011
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发表时间：
2013-11
期刊：
影响因子：
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通讯作者：
Jianzhong Ma;Qunna Xu;Jianhua Zhou;Jing Zhang;Limin Zhang;Huiru Tang;Lihong Chen
中科院分区：
文献类型：
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作者：
Jianzhong Ma;Qunna Xu;Jianhua Zhou;Jing Zhang;Limin Zhang;Huiru Tang;Lihong Chen
酪蛋白具有许多有趣的性质，使其成为传统和新型药物递送系统的良好候选者。本研究采用双原位法制备了酪蛋白基二氧化硅纳米复合材料，并用透射电子显微镜对所制得的乳胶粒的形貌和尺寸进行了表征。用扫描电子显微镜(SEM)和能量色散X射线(EDX)研究了薄膜的形貌，讨论了薄膜的力学性能和响应行为随二氧化硅含量的变化规律。以布洛芬为模型药物。通过固体核磁共振(固态核磁共振)、傅立叶变换红外光谱(FT-IR)、扫描电子显微镜(SEM)和体外实验研究了其载药和释药特性。复合胶乳粒子具有稳定的核壳结构，薄膜表面规则，二氧化硅分布均匀。由于药物在二氧化硅表面的吸附作用，随着二氧化硅的加入，复合膜的载药效率提高。在酸性释放介质中，布洛芬复合制剂的释药速度随二氧化硅含量的增加而降低。这些行为很可能是由于二氧化硅和药物之间的相互作用降低了药物在复合微球中的扩散速度。
Casein possesses many interesting properties that make it a good candidate for conventional and novel drug delivery systems. In this study, casein-based silica nano-composite was prepared via double in situ method, and the as-prepared latex particles were evaluated in terms of their morphology and size through transmission electron microscopy (TEM). The film morphology was investigated by scanning electron microscopy (SEM) and energy dispersive X-ray (EDX), and the mechanical property and response behavior of the films as a function of silica content were discussed. Ibuprofen was used as the model drug. The drug load and release properties were studied by solid-state nuclear magnetic resonance (solid-state NMR), Fourier transform infrared (FT-IR), SEM and in vitro test. The composite latex particle showed a stable core–shell structure, and the film exhibited a regular surface with even SiO2distribution. The drug load efficiency of the composite films increased with adding silica because of the adsorption of the drugs on the silica. In an acidic release medium, the ibuprofen-loaded composite showed a slower drug release dependent on the silica content. These behaviors were most likely due to the reduced diffusion rate of the drug through the composite microsphere, which resulted from the interaction between the silica and the drug.