Translational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation.
Translational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation.
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啮齿动物海马听觉门控在精神分裂症研究中的转化效用：回顾和评估。
DOI：
10.1038/tp.2015.77
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发表时间：
2015
影响因子：
6.8
通讯作者：
Tregellas,JR
中科院分区：
文献类型：
--
作者：
Smucny,J;Stevens,KE;Olincy,A;Tregellas,JR
听觉诱发P50电位门控受损是精神分裂症最具特征的特征之一。在啮齿动物中，这种缺陷最常见的模型是通过植入电极记录来自啮齿动物P50类似物P20-N40的海马体。然而，这一工具的有效性和效力尚未得到系统审查。在这里，我们总结了研究结果，研究了药理学调制门控啮齿动物海马P20-N40和人类P50的影响。我们表明，药物对P20-N40的影响在相似的剂量范围内高度预测人体效应。此外，精神状态（例如，麻醉与警觉）似乎不会降低这些记录的预测能力。然后，我们讨论了假设的神经药理学机制，可能是每种药物研究的门控效应的基础。总之，这篇综述支持继续使用海马P20-N40门控作为精神分裂症研究的翻译工具。
Impaired gating of the auditory evoked P50 potential is one of the most pharmacologically well-characterized features of schizophrenia. This deficit is most commonly modeled in rodents by implanted electrode recordings from the hippocampus of the rodent analog of the P50, the P20–N40. The validity and effectiveness of this tool, however, has not been systematically reviewed. Here, we summarize findings from studies that have examined the effects of pharmacologic modulation on gating of the rodent hippocampal P20–N40 and the human P50. We show that drug effects on the P20–N40 are highly predictive of human effects across similar dose ranges. Furthermore, mental status (for example, anesthetized vs alert) does not appear to diminish the predictive capacity of these recordings. We then discuss hypothesized neuropharmacologic mechanisms that may underlie gating effects for each drug studied. Overall, this review supports continued use of hippocampal P20–N40 gating as a translational tool for schizophrenia research.