Application of olfactory tissue and its neural progenitors to schizophrenia and psychiatric research.
Application of olfactory tissue and its neural progenitors to schizophrenia and psychiatric research.
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DOI：
10.1097/yco.0000000000000327
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发表时间：
2017-05
影响因子：
6.9
通讯作者：
Ishizuka K
中科院分区：
文献类型：
--
作者：
Lavoie J;Sawa A;Ishizuka K
这篇综述文章的目的是介绍嗅上皮 (OE) 衍生的细胞/组织模型作为一种有前途的替代系统，用于研究精神分裂症 (SZ) 和其他神经精神疾病所涉及的分子机制。在这里，我们特别关注它们的神经祖细胞的效用。最近使用 OE 衍生的组织/细胞模型对 SZ 的病理生理学进行了研究，提供了有关 SZ 相关的神经发育、应激反应和基因/蛋白质表达调控途径改变的见解。由于神经干细胞和祖细胞的存在，OE 保留了终生神经发生和再生的能力。因此，成熟的神经元和神经祖细胞都可以从 OE 中获得，而不需要遗传重编程和相关的混淆。此外，OE 在翻译环境中是高度可扩展的资源。在这里，我们还展示了使用 OE 衍生的组织/细胞模型治疗 SZ 和其他脑部疾病的最新研究结果。总之，我们建议 OE 作为研究与 SZ 和其他精神障碍病理学相关的神经分子和细胞特征的有前途的资源。
The goal of this review article is to introduce olfactory epithelium (OE)-derived cell/tissue models as a promising surrogate system to study the molecular mechanisms implicated in schizophrenia (SZ) and other neuropsychiatric disorders. Here we particularly focus the utility of their neural progenitors. Recent investigations of the pathophysiology of SZ using OE-derived tissue/cell models have provided insights about SZ-associated alterations in neurodevelopment, stress response, and gene/protein expression regulatory pathways. The OE retains the capacity for lifelong neurogenesis and regeneration, because of the presence of neural stem cells and progenitors. Thus, both mature neurons and neural progenitors can be obtained from the OE without the need for genetic reprogramming and related confounds. Furthermore, the OE is highly scalable resource in translational settings. Here we also demonstrate recent findings from research using OE-derived tissue/cell models in SZ and other brain disorders. In summary, we propose that the OE as a promising resource to study neural molecular and cellular signatures relevant to the pathology of SZ and other mental disorders.