Biological activity of enantiomerically pure forms of insect juvenile hormone I and III inBombyx mori
Biological activity of enantiomerically pure forms of insect juvenile hormone I and III inBombyx mori
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家蚕中昆虫保幼激素 I 和 III 对映体纯形式的生物活性
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
K. Mori
中科院分区：
文献类型：
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作者：
S. Sakurai;T. Ohtaki;H. Mori;M. Fujiwhara;K. Mori
通过局部应用对映体纯幼体激素对去甲家蚕4龄幼虫的生物活性进行了研究。所测试的JHs为(10R)-JH I[甲基(2E,6E,10R,11S)-10,11-环氧-3,11-二甲基-7-乙基-2,6-三癸酸酯]，(10S)-JH I[甲基(2E,6E,10S, 11R)-10,11-环氧-3,11-二甲基-2,6-三甲基-二癸酸酯]，(10R)-JH III[甲基(2E,6E,10R)-10,11-环氧-3,7,11-三甲基-2,6-十二癸酸酯]和(10S)-JH III[甲基(2E,6E,10S)-10,11-环氧-3,7,11-三甲基-2,6-十二癸酸酯]。其中天然(10R)-JH I活性最强，诱导50%幼虫蜕皮所需剂量为0.04 μg/幼虫；天然(10R)-JH III表现出轻微的生物活性，但仅为(10R)-JH i的千分之一。非天然(10S)-JH III在所测水平上没有表现出生物活性。
Biological activity of enantiomerically pure juvenile hormones was assayed by topical application on allatectomizedBombyx fourth instar larvae. JHs tested were (10R)-JH I [methyl (2E,6E,10R,11S)-10,11-epoxy-3,11-dimethyl-7-ethyl-2,6-tridecadienoate], (10S)-JH I [methyl (2E, 6E, 10S, 11R)-10,11-epoxy-3,11-dimethyl-7-ethyl-2,6-tridecadienoate], (10R)-JH III [methyl (2E,6E,10R)-10,11-epoxy-3,7,11-trimethyl-2,6-dodecadienoate] and (10S)-JH III [methyl (2E,6E,10S)-10,11-epoxy-3,7,11-trimethyl-2,6-dodecadienoate]. Among these compounds, natural (10R)-JH I was most active and the dose needed to induce 50% larval molting was 0.04 μg/larva; it was approximately 12,000 times more active than unnatural (10S)-JH I. Though natural (10R)-JH III showed slight biological activity, it was only one three-thousandth of that of (10R)-JH I. Unnatural (10S)-JH III exhibited no biological activity at the levels assayed.
烟草天蛾（Manduca sexta）促促胸腺激素的释放本质上是由保幼激素控制的。
DOI：
10.1242/jeb.120.1.41
发表时间：
1986
期刊：
The Journal of experimental biology
影响因子：
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作者：
Rountree,DB;Bollenbacher,WE
通讯作者：
Bollenbacher,WE