Stroke Treatment Academic Industry Roundtable (STAIR) Recommendations for Maximizing the Use of Intravenous Thrombolytics and Expanding Treatment Options With Intra-arterial and Neuroprotective Therapies
Stroke Treatment Academic Industry Roundtable (STAIR) Recommendations for Maximizing the Use of Intravenous Thrombolytics and Expanding Treatment Options With Intra-arterial and Neuroprotective Therapies
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DOI：
10.1161/strokeaha.111.618850
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发表时间：
2011-09-01
期刊：
影响因子：
8.3
通讯作者：
Saver, Jeffrey L.
中科院分区：
文献类型：
--
作者：
Albers, Gregory W.;Goldstein, Larry B.;Saver, Jeffrey L.
背景和目的 - 中风治疗学术行业圆桌会议（楼梯）会议的目标是提高急性和恢复性中风疗法的发展。审查的夏季 - 楼梯VII的建议，提出了通过针对公共教育和当前治疗治疗方法的重新选择的策略，以最大程度地利用静脉内血栓形成术的使用。可以通过在随机临床试验中获得更确定的疗效证据，确定与治疗疗效相关的患者特征，技术方法优化，有效的时间窗口的澄清以及方法来限制复杂性，可以通过获得更确定的疗效证据来实现机械设备的利用来增加动力内再续化。神经保护策略仍然可行；对这些药物进行进一步研究的建议包括强调快速给药，考虑缺血性中风的全身效应，预防与早期再灌注相关的并发症，重点是具有多种作用机制的药物以及对神经proptifeentaptionaltife的相互作用以及对神经性的相互作用的考虑。再灌注疗法以及神经保护疗法的进一步发展是楼梯VII的关键建议。 （Stroke。2011; 42：2645-2650。）
Background and Purpose-The goal of the Stroke Treatment Academic Industry Roundtable (STAIR) meetings is to advance the development of acute and restorative stroke therapies.Summary of Review-At the STAIR VII recommendations for strategies to maximize the use of intravenous thrombolytics through targeting public education, and the refinement of current treatment exclusion criteria were proposed. Increased utilization of mechanical devices for intra-arterial recanalization can be achieved by obtaining more definitive evidence of efficacy in randomized clinical trials, identification of patient characteristics associated with treatment efficacy, optimization of technical approaches, clarification of effective time windows, and development of approaches to limit complications. Neuroprotective strategies remain viable; recommendations for further study of these agents include an emphasis on rapid administration, consideration of the systemic effects of ischemic stroke, prevention of complications associated with early reperfusion, a focus on agents with multiple mechanisms of action, and consideration of possible interactions between neuroprotective and thrombolytic therapies.Conclusions-Extending intravenous thrombolysis to a broader patient population, clarifying the risk and benefits of intra-arterial reperfusion therapies, and further development of neuroprotective therapies were the key recommendations from STAIR VII. (Stroke. 2011;42:2645-2650.)