Distribution and Heritability of Iris Thickness and Pupil Size in Chinese: The Guangzhou Twin Eye Study
Distribution and Heritability of Iris Thickness and Pupil Size in Chinese: The Guangzhou Twin Eye Study
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中国人虹膜厚度和瞳孔大小的分布和遗传力：广州双胞胎研究
DOI：
10.1167/iovs.08-2735
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发表时间：
2009-04-01
影响因子：
4.4
通讯作者：
Huang, Wenyong
中科院分区：
文献类型：
--
作者：
He, Mingguang;Wang, Dandan;Huang, Wenyong
目的。通过对一对经典双胞胎的研究，探讨前段光学相干断层扫描（ASOCT）测量的虹膜厚度和瞳孔直径的分布和遗传力。8至16岁的双胞胎从广州双胞胎登记处登记。用ASOCT获得一幅水平扫描，用定制软件对图像进行分析。在距巩膜骨刺750 μ m （IT750）和2000 μ m （IT2000）处测量虹膜厚度，以及虹膜累积面积（IAREA）。在鼻侧和颞侧虹膜最中心点之间测量以毫米为单位的瞳孔直径。通过基因分型证实了所有同性双胞胎的合子性。用Mx程序调整年龄和性别后，采用结构方差成分遗传模型评估遗传力。参与分析的是309对同卵双胞胎（MZ）和165对异卵双胞胎（DZ）。平均IT750、IT2000和IAREA分别为0.406 +/- 0.075 (SD) mm、0.514 +/- 0.075 mm和1.169 +/- 0.184 mm(2)，而PDMM为5.600 +/- 0.0821 mm。IT750、IT2000、IAREA和PDMM的类内相关系数MZ分别为0.53、0.54、0.61和0.63，DZ分别为0.29、0.11、0.35和0.34。具有加性遗传和独特环境效应的模型最为简约，虹膜厚度和瞳孔直径的遗传率约为60%。女孩的虹膜厚度较薄，但儿童的虹膜厚度与年龄无关。这种变异在很大程度上可归因于加性遗传效应。（中国眼科杂志，2009;50:1593- 1597）DOI:10.1167/iovs.08-2735
PURPOSE. To investigate the distribution and heritability of iris thickness and pupil diameter measured by anterior segment optical coherence tomography (ASOCT) in a classic twin study.METHODS. Twins aged 8 to 16 years were enrolled from the Guangzhou Twin Registry. ASOCT was used to obtain one horizontal scan, and the images were analyzed with custom software. Iris thickness was measured at 750 mu m (IT750) and 2000 mu m (IT2000) from the scleral spur, as well as cumulative iris area (IAREA). Pupil diameter in millimeters (PDMM) was measured between the most central points of the iris at the nasal and temporal sides. Zygosity was confirmed by genotyping in all same-sex twin pairs. Heritability was assessed by structural variance component genetic modeling after adjustment for age and sex with the Mx program.RESULTS. Participating in the analysis were 309 monozygotic (MZ) and 165 dizygotic (DZ) twin pairs. The mean IT750, IT2000, and IAREA were 0.406 +/- 0.075 (SD) mm, 0.514 +/- 0.075 mm, and 1.169 +/- 0.184 mm(2), whereas the PDMM was 5.600 +/- 0.0821 mm. The intraclass correlation coefficients for the IT750, IT2000, IAREA, and PDMM were 0.53, 0.54, 0.61, and 0.63 for MZ pairs and 0.29, 0.11, 0.35, and 0.34 for DZ pairs, respectively. A model with additive genetic and unique environmental effect was the most parsimonious, and the heritability was approximately 60% for iris thickness and pupil diameter.CONCLUSIONS. Iris thickness is thinner in girls but is not associated with age in children. The variation is largely attributable to additive genetic effects. (Invest Ophthalmol Vis Sci. 2009; 50: 1593- 1597) DOI:10.1167/iovs.08-2735