Reactivity of chloroacetylated β-enamino compounds.: Synthesis of heterocycles
Reactivity of chloroacetylated β-enamino compounds.: Synthesis of heterocycles
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DOI：
10.1016/s0040-4039(02)01961-5
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发表时间：
2002-11-04
影响因子：
1.8
通讯作者：
Martins, DB
中科院分区：
文献类型：
--
作者：
Braibante, MEF;Braibante, HTS;Martins, DB
由β-氨基α，β-不饱和酮1a和酯1c-g与氯乙酰氯反应，合成了（E）-（3-氨基取代）-2-氯乙酰基-2-丁烯酸乙酯2c-g、N-[（Z）-1-甲基-3-氧代-1-丁烯基]-2-氯乙酰胺3a和（Z）-3-氯甲基甲氨基-2-丁烯酸乙酯3c。这些化合物的反应性进行了研究，通过与双核亲，如肼和羟胺的反应，以评估在形成的多官能化的杂环化合物的亲电中心。(C)2002年由Elsevier Science Ltd.出版
Ethyl (E)-(3-amino substituted)-2-chloroacetyl-2-butenoates 2c-g, N-[(Z)-1-methyl-3-oxo-1-butenyl]-2-chloroacetamide 3a and ethyl (Z)-3-chloromethyl carboxamino-2-butenoate 3c, have been prepared from beta-amino alpha,beta-unsaturated ketone 1a and esters 1c-g and chloroacetyl chloride. The reactivity of these compounds was studied by the reactions with binucleophiles, such as hydrazine and hydroxylamine, to evaluate the electrophilic centers in the formation of the polyfunctionalized heterocyclic compounds. (C) 2002 Published by Elsevier Science Ltd.