Reshapable hydrogel tissue expander for ridge augmentation: Results of a series of successive insertions at the same intraoral site.
Reshapable hydrogel tissue expander for ridge augmentation: Results of a series of successive insertions at the same intraoral site.
复制标题
用于牙槽嵴增高的可重塑水凝胶组织扩张器：在同一口内部位进行一系列连续插入的结果。
DOI：
10.1002/jper.18-0629
复制
发表时间：
2019
影响因子：
4.3
通讯作者：
Barco,ClarkT
中科院分区：
文献类型：
--
作者：
Garner,John;Davidson,DarrellD;Barwinska,Daria;Eckert,GeorgeJ;Tholpady,SunilS;Park,Kinam;Barco,ClarkT
背景：牙槽嵴增高术前的口腔黏膜扩张术是一种减少软组织暴露，提高植骨密度和体积的手术。本研究探讨了一种新的，可塑形的水凝胶组织扩张器（HTE）在口内网站，经历了以前的扩张和surgery.MethodsNine比格犬所有前磨牙提取和相邻的牙槽骨减少。至少3个月愈合后，将水凝胶放置在每只犬的4个部位：上颌骨和下颌骨，右侧和左侧。膨胀6周后，取出水凝胶并测量体积膨胀和物理条件。对扩张的口腔粘膜进行打孔活检。3个月后，在每个相同部位进行第二次水凝胶插入。在第二次扩张循环后，记录体积和水凝胶状态。三只狗在第二次扩张期间接受水凝胶的超声成像。尸检标本均采取了扩大和非扩大的口腔mucosa.ResultsWithin 2周后，HTE插入在第一次和第二次insertion，血流恢复到插入前的水平。第一次和第二次插入分别导致8.13 mm和6.44 mm的线性口腔粘膜增益。第一和第二插入水凝胶从4%的第一扩张部位和3%的第二扩张部位喷出。在任何部位均未发现扩张水凝胶的定向迁移。组织学发现几乎没有炎症反应，任何水凝胶implant.Conclusionoral粘膜可以一贯和成功地扩大骨移植前的脊增强，即使在网站的历史，以前的手术。
BackgroundOral mucosa expansion before ridge augmentation is a procedure to reduce soft tissue exposure and to improve bone graft density and volume after augmentation. This study explored a novel, shapeable hydrogel tissue expander (HTE) in intraoral sites that had undergone previous expansion and surgery.MethodsNine beagle dogs had all premolar teeth extracted and adjacent alveolar bone reduced. After at least 3 months healing hydrogels were placed at 4 sites in each dog: maxilla and mandible, right and left. After 6 weeks of expansion, the hydrogels were removed and measured for volume expansion and physical condition. Punch biopsies were taken of the expanded oral mucosa. After 3 months, a second hydrogel insertion was performed at each of the same sites. After this second expansion cycle, volume and hydrogel condition were recorded. Three dogs received ultrasound imaging of the hydrogels during the second expansion. Necropsy specimens were taken of both expanded and non‐expanded oral mucosa.ResultsWithin 2 weeks after HTE insertion in both first and second insertions, blood flow returned to the pre‐insertion level. The first and second insertions resulted in linear oral mucosa gain of 8.13 mm, and 6.44 mm, respectively. First and second insertion hydrogels erupted from 4% of the first expansion sites, and 3% of the second expansion sites. There was no directional migration of the expanding hydrogel at any site. Histology found little inflammatory reaction to any hydrogel implant.ConclusionOral mucosa can be consistently and successfully expanded before bone graft for ridge augmentation even at sites with a history of prior surgeries.