Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation.
Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation.
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DOI：
10.3389/fimmu.2015.00335
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发表时间：
2015
影响因子：
7.3
通讯作者：
Saveanu L
中科院分区：
文献类型：
--
作者：
Adiko AC;Babdor J;Gutiérrez-Martínez E;Guermonprez P;Saveanu L
交叉呈递，其中外源性抗原通过MHC I复合物呈递，涉及抗感染和抗肿瘤细胞毒性CD8+ T细胞的产生以及免疫耐受的维持。虽然交叉呈递在近四十年前就被描述了，虽然现在已经确定一些树突状细胞（DC）亚群在处理和交叉呈递内化抗原方面比其他亚群更好，但所涉及的分子机制仍然只有部分了解。交叉呈递中的一些最少探索的分子机制涉及交叉呈递MHCI分子的起源和抗原肽加载发生的细胞区室。本文综述了MHC I分子及其在细胞内的转运。我们讨论了DC中交叉呈递MHC I的来源以及内吞途径在其从细胞表面回收中的作用。接下来，我们描述了TAP肽转运蛋白在交叉呈递过程中将肽递送至MHC I的重要性。最后，我们强调了先天免疫机制对特异性抗原交叉呈递机制的影响，其中TLR激活调节MHC I贩运和TAP定位。
Cross-presentation, in which exogenous antigens are presented via MHC I complexes, is involved both in the generation of anti-infectious and anti-tumoral cytotoxic CD8+ T cells and in the maintenance of immune tolerance. While cross-presentation was described almost four decades ago and while it is now established that some dendritic cell (DC) subsets are better than others in processing and cross-presenting internalized antigens, the involved molecular mechanisms remain only partially understood. Some of the least explored molecular mechanisms in cross-presentation concern the origin of cross-presenting MHC I molecules and the cellular compartments where antigenic peptide loading occurs. This review focuses on MHC I molecules and their intracellular trafficking. We discuss the source of cross-presenting MHC I in DCs as well as the role of the endocytic pathway in their recycling from the cell surface. Next, we describe the importance of the TAP peptide transporter for delivering peptides to MHC I during cross-presentation. Finally, we highlight the impact of innate immunity mechanisms on specific antigen cross-presentation mechanisms in which TLR activation modulates MHC I trafficking and TAP localization.
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影响因子：
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作者：
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影响因子：
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DOI：
10.1073/pnas.0810059106
发表时间：
2009-02-17
影响因子：
11.1
作者：
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通讯作者：
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