B effector cells in rheumatoid arthritis and experimental arthritis
B effector cells in rheumatoid arthritis and experimental arthritis
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DOI：
10.3109/08916934.2012.665526
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发表时间：
2012-08-01
期刊：
影响因子：
3.5
通讯作者：
Hamel, Keith M.
中科院分区：
文献类型：
--
作者：
Finnegan, Alison;Ashaye, Susan;Hamel, Keith M.
类风湿性关节炎是一种慢性自身免疫性疾病，影响约 1% 的人口。基于 B 细胞耗竭疗法可有效治疗疾病的证据，人们对 B 细胞在类风湿性关节炎中的作用重新产生了兴趣。这篇综述总结了 B 细胞导致自身免疫性关节炎的机制的当前知识，包括作为自身抗体产生细胞、抗原呈递细胞、细胞因子产生细胞和调节细胞的作用。
Rheumatoid arthritis is a chronic autoimmune immune disease affecting approximately 1% of the population. There has been a renewed interest in the role of B cells in rheumatoid arthritis based on the evidence that B cell depletion therapy is effective in the treatment of disease. This review summarizes the current knowledge of the mechanisms by which B cells contribute to autoimmune arthritis including roles as autoantibody producing cells, antigen-presenting cells, cytokine producing cells, and regulatory cells.