Neuroblastoma with ovarian and pancreatic metastasis
Neuroblastoma with ovarian and pancreatic metastasis
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DOI：
10.1016/j.epsc.2021.101996
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发表时间：
2021-08-13
影响因子：
0.4
通讯作者：
Ikawa, Yasuhiro
中科院分区：
文献类型：
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作者：
Sakai, Seisho;Nomura, Kozo;Ikawa, Yasuhiro
神经母细胞瘤转移到胰腺和卵巢是罕见的。我们报告一个12岁的女孩被诊断为原发性左肾上腺神经母细胞瘤，并转移到局部淋巴结、左眼眶、左卵巢和多块骨头。化疗4个疗程后，眼眶、骨转移灶消失；卵巢肿瘤仍然存在，淋巴结转移显示为胰腺转移。左肾上腺肿瘤切除，保脾部分胰腺切除，左卵巢切除。手术标本病理检查显示卵巢有活的肿瘤细胞，胰腺无。术后行化疗、自体骨髓移植、I-131-MIBG放疗及放疗。本病例是一个罕见的转移部位可以切除的病例，认为转移途径、化疗反应性的评价、转移灶切除的指征有很多值得讨论的地方。
Neuroblastoma metastasis to the pancreas and ovaries is rare. We report a 12-year-old girl diagnosed with primary left adrenal neuroblastoma and metastases to the local lymph nodes, left orbit, left ovary, and multiple bones. After 4 courses of chemotherapy, the orbital and bone metastases disappeared; the ovarian tumor remained and the lymph node metastases were shown to be pancreatic metastases. Left adrenal tumor resection with spleen-preserving partial pancreas resection and left ovariectomy was performed. Pathological examination of surgical specimens showed viable tumor cells in the ovary but none in the pancreas. Additional chemotherapy, autologous bone marrow transplantation, I-131-MIBG radiotherapy, and radiation therapy were performed after surgery. This case was a case where it was possible to resect a rare metastatic site, and it is thought that there are many points to discuss about the metastatic pathway, evaluation about reactivity of chemotherapy, and indication about excision of metastatic lesions.